Department of Radiology, Koç University Faculty of Medicine, İstanbul, Turkey.
Medical Student, Koç University Faculty of Medicine, İstanbul, Turkey.
Diagn Interv Radiol. 2023 Jul 20;29(4):363-370. doi: 10.4274/dir.2022.221730. Epub 2022 Dec 21.
To investigate the relationship between hepatic steatosis (HS), pancreatic steatosis (PS), and coexisting HS and PS and the Coronavirus disease-2019 (COVID-19) pneumonia total severity score (TSS) and prognosis, assessed through computed tomography (CT), and to evaluate the degree of effectiveness of the three steatosis conditions on TSS and prognosis.
This retrospective study involved 461 patients (255 male and 206 female, median age of 53 years) with COVID-19 who underwent unenhanced chest CT. HS, PS, and coexisting HS and PS, assessed through CT, were compared with patient demographics, comorbidities, TSS, hospitalization and intubation requirements, and mortality rates. The parameters were compared using Mann-Whitney U and chi-square tests. The parameters of three groups of patients with only HS, only PS, and both HS and PS were compared using the Kruskal-Wallis test.
Results revealed that TSS ( < 0.001 for all) and hospitalization rates ( < 0.001 for all except for HS [ = 0.004]) were higher in patients with HS, PS, and both than in those without. Intubation ( = 0.003) and mortality rates ( = 0.018) were significantly higher solely in patients with PS. However, TSS, hospitalization, and diabetes mellitus were significantly higher than in age-standardized analyses for PS. In a comparison between only HS, only PS, and coexisting HS and PS in 210 patients, the highest TSS was in the coexistence group ( < 0.001).
The TSS and hospitalization rates correlate with HS, PS, and coexisting HS and PS, whereas intubation and mortality rates only correlate with PS. However, TSS correlates with coexisting HS and PS at the highest rate.
通过计算机断层扫描（CT）评估肝脂肪变性（HS）、胰腺脂肪变性（PS）以及共存的 HS 和 PS 与 2019 年冠状病毒病（COVID-19）肺炎总严重程度评分（TSS）和预后的关系，并评估这三种脂肪变性情况对 TSS 和预后的有效性程度。
本回顾性研究纳入了 461 名 COVID-19 患者（255 名男性，206 名女性，中位年龄 53 岁），均接受了未增强胸部 CT 检查。通过 CT 评估 HS、PS 以及共存的 HS 和 PS，并将其与患者的人口统计学特征、合并症、TSS、住院和插管需求以及死亡率进行比较。采用 Mann-Whitney U 和卡方检验对参数进行比较。采用 Kruskal-Wallis 检验比较仅存在 HS、仅存在 PS 以及同时存在 HS 和 PS 的三组患者的参数。
结果显示，在存在 HS、PS 以及共存的 HS 和 PS 的患者中，TSS（均<0.001）和住院率（均<0.001，除了 HS[=0.004]）均高于无 HS、PS 以及共存的 HS 和 PS 的患者。仅 PS 患者的插管率（=0.003）和死亡率（=0.018）显著更高。然而，在 PS 的年龄标准化分析中，TSS、住院和糖尿病的发生率显著更高。在 210 例仅存在 HS、仅存在 PS 和共存的 HS 和 PS 的患者之间进行比较时，共存组的 TSS 最高（<0.001）。
TSS 和住院率与 HS、PS 以及共存的 HS 和 PS 相关，而插管率和死亡率仅与 PS 相关。然而，TSS 与共存的 HS 和 PS 的相关性最高。
