1Department of Small Animal Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC.
2Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX.
J Am Vet Med Assoc. 2024 Aug 21;262(10):1305-1313. doi: 10.2460/javma.24.07.0434. Print 2024 Oct 1.
Acid-suppressant drugs (ASDs) have revolutionized the treatment of acid-related disorders such as gastroesophageal reflux and gastrointestinal ulceration in both human and veterinary species. However, continued advancement in this field is dependent on a shared understanding of both human and veterinary research as well as an appreciation for species similarities and differences. In this Currents in One Health article, we will compare the efficacy of and indications for ASDs in humans and small animals, noting species differences and knowledge gaps when applicable. We will also highlight areas where further research is needed, specifically emphasizing the need for more feline research and a better understanding of which diseases may benefit from gastroprotection. Finally, given the rising overuse of ASDs in both human and veterinary medicine, we will explore the known adverse effects of these drugs in dogs and cats. This article is focused on our current understanding of these drugs in veterinary medicine and their clinical implications. The companion Currents in One Health article by Gould et al, AJVR, October 2024, will explore the future of ASD research and use by evaluating these drugs' pH-independent effects in humans and rodent models.
抑酸药物（ASD）彻底改变了酸相关疾病的治疗方法，例如人类和兽医物种中的胃食管反流和胃肠道溃疡。然而，该领域的持续进步依赖于对人类和兽医研究的共同理解，以及对物种相似性和差异性的认识。在这篇《One Health 动态》文章中，我们将比较 ASD 在人类和小型动物中的疗效和适应证，并指出适用的物种差异和知识空白。我们还将重点介绍需要进一步研究的领域，特别是强调需要对猫科动物进行更多的研究，并更好地了解哪些疾病可能受益于胃保护。最后，鉴于 ASD 在人类和兽医医学中的过度使用不断增加，我们将探讨这些药物在狗和猫中的已知不良反应。本文重点介绍了我们目前对兽医医学中这些药物的理解及其临床意义。Gould 等人的《AJVR》2024 年 10 月刊的配套《One Health 动态》文章将通过评估这些药物在人类和啮齿动物模型中的 pH 非依赖性作用，探索 ASD 研究和应用的未来。
