Suppr超能文献

解析 SARS-CoV2 蛋白在 COVID-19 发病机制和治疗学中的结构和功能维度。

Unraveling the structural and functional dimensions of SARS-CoV2 proteins in the context of COVID-19 pathogenesis and therapeutics.

机构信息

Department of Biophysics, All India Institute of Medical Sciences, New Delhi, India.

Department of Biophysics, All India Institute of Medical Sciences, New Delhi, India.

出版信息

Int J Biol Macromol. 2024 Oct;278(Pt 2):134850. doi: 10.1016/j.ijbiomac.2024.134850. Epub 2024 Aug 20.

Abstract

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) has emerged as the causative agent behind the global pandemic of Coronavirus Disease 2019 (COVID-19). As the scientific community strives to comprehend the intricate workings of this virus, a fundamental aspect lies in deciphering the myriad proteins it expresses. This knowledge is pivotal in unraveling the complexities of the viral machinery and devising targeted therapeutic interventions. The proteomic landscape of SARS-CoV2 encompasses structural, non-structural, and open-reading frame proteins, each playing crucial roles in viral replication, host interactions, and the pathogenesis of COVID-19. This comprehensive review aims to provide an updated and detailed examination of the structural and functional attributes of SARS-CoV2 proteins. By exploring the intricate molecular architecture, we have highlighted the significance of these proteins in viral biology. Insights into their roles and interplay contribute to a deeper understanding of the virus's mechanisms, thereby paving the way for the development of effective therapeutic strategies. As the global scientific community strives to combat the ongoing pandemic, this synthesis of knowledge on SARS-CoV2 proteins serves as a valuable resource, fostering informed approaches toward mitigating the impact of COVID-19 and advancing the frontier of antiviral research.

摘要

严重急性呼吸综合征冠状病毒 2(SARS-CoV2)已成为导致 2019 年冠状病毒病(COVID-19)全球大流行的病原体。随着科学界努力理解这种病毒的复杂工作原理,一个基本方面在于破译它表达的众多蛋白质。这些知识对于揭示病毒机制的复杂性和设计靶向治疗干预措施至关重要。SARS-CoV2 的蛋白质组学景观包括结构蛋白、非结构蛋白和开放阅读框蛋白,它们在病毒复制、宿主相互作用和 COVID-19 的发病机制中都发挥着关键作用。本综述旨在提供对 SARS-CoV2 蛋白的结构和功能属性的最新和详细检查。通过探索复杂的分子结构,我们强调了这些蛋白质在病毒生物学中的重要性。对其作用和相互作用的深入了解有助于加深对病毒机制的理解,从而为开发有效的治疗策略铺平道路。随着全球科学界努力应对当前的大流行,对 SARS-CoV2 蛋白的知识综合为减轻 COVID-19 影响和推进抗病毒研究前沿提供了有价值的资源,促进了知情的方法。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验