Ripa Matteo, Schipa Chiara, Aceto Paola, Tshomba Yamume, Rizzo Stanislao, Baldascino Antonio, Donati Tommaso
Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy.
Catholic University "Sacro Cuore," Rome, Italy.
Eur J Ophthalmol. 2025 Mar;35(2):409-428. doi: 10.1177/11206721241277247. Epub 2024 Aug 22.
The role of carotid artery disease (CAD) in the development of various types of ocular arterial occlusive disorders has often been reported. This systematic review aims to evaluate and review the current evidence regarding the role of CAD and the subsequent carotid artery hemodynamic alterations in the development of non-arteritic anterior (NA-AION) and posterior (NA-PION) ischemic optic neuropathy.
We systematically reviewed studies following Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. We systematically searched PubMed, Embase, and Scopus databases for relevant studies that clearly assessed the role of CAD and the subsequent carotid artery hemodynamic alterations in the development of NA-AION and NA-PION. All studies that examined the associations between CAD and the development of NA-AION and NA-PION in adults aged 18 years or older were synthesized. Quality assessment using the Newcastle-Ottawa Scale (NOS), and Joanna Briggs Institute (JBI) Critical Appraisal Checklist for Case Reports and Case-Series were also conducted.
Our search identified 1933 manuscripts published in the English language. The number of participants with non-arteritic ischemic optic neuropathy (NA-ION) ranged from 1 to 191, with a total of 478 patients experiencing either NA-AION (410 out of 478), NA-PION (13 out of 478), or a combination of thereof (1 out of 478). The number of participants with NA-ION due to atherosclerosis ranged from 1 to 191, with a total of 376 patients.
Although carotid artery disease may rarely contribute to the development of NA-ION, it should be considered as a possible cause of NA-ION.
颈动脉疾病（CAD）在各类眼部动脉闭塞性疾病发展过程中的作用已有诸多报道。本系统评价旨在评估和综述关于CAD及其后续颈动脉血流动力学改变在非动脉炎性前部（NA - AION）和后部（NA - PION）缺血性视神经病变发展中作用的现有证据。
我们按照系统评价和Meta分析的首选报告项目指南进行系统评价。我们在PubMed、Embase和Scopus数据库中系统检索相关研究，这些研究需明确评估CAD及其后续颈动脉血流动力学改变在NA - AION和NA - PION发展中的作用。纳入所有研究18岁及以上成年人中CAD与NA - AION和NA - PION发展之间关联的研究。还使用纽卡斯尔 - 渥太华量表（NOS）以及乔安娜·布里格斯研究所（JBI）病例报告和病例系列的批判性评价清单进行质量评估。
我们的检索共识别出1933篇英文发表的手稿。非动脉炎性缺血性视神经病变（NA - ION）参与者人数从1至191不等，共有478例患者，其中410例为NA - AION，13例为NA - PION，或两者皆有（1例）。因动脉粥样硬化导致NA - ION的参与者人数从1至191不等，共有376例患者。
尽管颈动脉疾病可能很少导致NA - ION的发生，但应将其视为NA - ION的一个可能病因。
