University of Science and Technology of China, Hefei 230026, China.
High Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui 230031, PR China.
ACS Appl Mater Interfaces. 2024 Sep 4;16(35):46079-46089. doi: 10.1021/acsami.4c09215. Epub 2024 Aug 22.
Phototherapy has demonstrated substantial development because in the second near-infrared (NIR-II) window it has a larger tissue penetration and fewer adverse consequences. In this work, a particular kind of NIR-II responsive Fe-doped carbon nanoparticles (FDCNs) is synthesized using a one-pot hydrothermal method for combined photothermal and chemodynamic therapy. The mesoporous nanostructure of FDCN, which has a size distribution that exceeds 225 nm, allows for effective acidification. The iron ions released from these nanoparticles can catalyze the decomposition of hydrogen peroxide (HO) into hydroxyl radical (•OH) for chemodynamic therapy (CDT). In addition to their CDT utility, FDCN can effectively adsorb and transform 1064 nm light into local heat, achieving a photothermal conversion efficacy (PCE) of 36.3%. This dual functionality not only allows for the direct eradication of cancer cells through photothermal therapy (PTT) but also enhances the chemodynamic reaction, creating a synergistic effect that amplifies the therapeutic outcome. The FDCN has demonstrated remarkable anticancer activity in both cellular and animal tests without incurring major systemic toxicity. This suggests that the compound has great promise for use in clinical cancer therapy.
光疗技术取得了显著的发展，因为在近红外二区（NIR-II）窗口，它具有更大的组织穿透性和更少的不良反应。在这项工作中，使用一锅水热法合成了一种特殊的近红外二区响应的 Fe 掺杂碳纳米粒子（FDCN），用于联合光热和化学动力学治疗。FDCN 的介孔纳米结构，其尺寸分布超过 225nm，允许有效酸化。这些纳米粒子释放的铁离子可以催化过氧化氢（HO）分解为用于化学动力学治疗（CDT）的羟基自由基（•OH）。除了它们的 CDT 用途外，FDCN 还可以有效吸附并将 1064nm 光转化为局部热量，实现 36.3%的光热转换效率（PCE）。这种双重功能不仅可以通过光热疗法（PTT）直接消除癌细胞，还可以增强化学动力学反应，产生协同效应，放大治疗效果。FDCN 在细胞和动物实验中均表现出显著的抗癌活性，而没有引起重大的全身毒性。这表明该化合物在临床癌症治疗中有很大的应用前景。
