Gao Huihui, Qian Beiran, Ni Yan, Sun Liying, Fu Junfen
（ 310052） National Clinical Research Center for Child Health, Department of Pediatric and Adolescent Gynecology, Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310052, China.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2024 Jul 20;55(4):1049-1054. doi: 10.12182/20240760208.
Polycystic ovary syndrome (PCOS) is one of the most common gynecological endocrine disorders. Most pathophysiological changes of PCOS begin in the peripubertal phase, and these pathophysiological changes will continuously affect women's health in the later stages of their lives. The pathogenic mechanisms of PCOS remain unclear, involving key aspects such as the regulation of hypothalamic-pituitary function, ovarian cellular functions, androgen levels, and insulin resistance. Herein, we summarized the latest findings on the pathogenesis of PCOS from the perspectives of the genetic background, intrauterine development, neuroendocrine function, inflammatory factors, gut microbiome, and environmental factors. This review will help provide new ideas for a deeper understanding of the disease, as well as its clinical diagnosis and treatment.
多囊卵巢综合征（PCOS）是最常见的妇科内分泌疾病之一。PCOS的大多数病理生理变化始于青春期前后阶段，这些病理生理变化将在女性生命的后期持续影响其健康。PCOS的发病机制仍不清楚，涉及下丘脑 - 垂体功能调节、卵巢细胞功能、雄激素水平和胰岛素抵抗等关键方面。在此，我们从遗传背景、子宫内发育、神经内分泌功能、炎症因子、肠道微生物群和环境因素等角度总结了PCOS发病机制的最新研究结果。本综述将有助于为更深入了解该疾病及其临床诊断和治疗提供新思路。
