多囊卵巢综合征中的肠道菌群失调：进展机制与临床应用。
Gut microbiota dysbiosis in polycystic ovary syndrome: Mechanisms of progression and clinical applications.
机构信息
Department of Anesthesiology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China.
Department of Obstetrics and Gynecology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China.
出版信息
Front Cell Infect Microbiol. 2023 Feb 24;13:1142041. doi: 10.3389/fcimb.2023.1142041. eCollection 2023.
Abstract
Polycystic ovary syndrome (PCOS) is the most common endocrine diseases in women of childbearing age that leads to menstrual disorders and infertility. The pathogenesis of PCOS is complex and has not yet been fully clarified. Gut microbiota is associated with disorders of lipid, glucose, and steroid hormone metabolish. A large body of studies demonstrated that gut microbiota could regulate the synthesis and secretion of insulin, and affect androgen metabolism and follicle development, providing us a novel idea for unravelling the pathogenesis of PCOS. The relationship between gut microbiota and the pathogenesis of PCOS is particularly important. This study reviewed recent research advances in the roles of gut microbiota in the occurrence and development of PCOS. It is expected to provide a new direction for the treatment of PCOS based on gut microbiota.
摘要
多囊卵巢综合征（PCOS）是育龄妇女最常见的内分泌疾病，可导致月经紊乱和不孕。PCOS 的发病机制复杂，尚未完全阐明。肠道微生物群与脂质、葡萄糖和类固醇激素代谢紊乱有关。大量研究表明，肠道微生物群可以调节胰岛素的合成和分泌，影响雄激素代谢和卵泡发育，为我们揭示 PCOS 的发病机制提供了新的思路。肠道微生物群与 PCOS 发病机制的关系尤为重要。本研究综述了近年来肠道微生物群在 PCOS 发生发展中的作用的研究进展，以期为基于肠道微生物群的 PCOS 治疗提供新的方向。
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