Lun Hengzhong, Li Peilong, Li Juan, Liu Fenfen
Department of Clinical Laboratory, The Affiliated Taian City Central Hospital of Qingdao University, Taian, Shandong, China.
Department of Clinical Laboratory, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Heliyon. 2024 Aug 3;10(15):e35755. doi: 10.1016/j.heliyon.2024.e35755. eCollection 2024 Aug 15.
Intestinal flora metabolites played a crucial role in immunomodulation by influencing host immune responses through various pathways. Macrophages, as a type of innate immune cell, were essential in chemotaxis, phagocytosis, inflammatory responses, and microbial elimination. Different macrophage phenotypes had distinct biological functions, regulated by diverse factors and mechanisms. Advances in intestinal flora sequencing and metabolomics have enhanced understanding of how intestinal flora metabolites affect macrophage phenotypes and functions. These metabolites had varying effects on macrophage polarization and different mechanisms of influence. This study summarized the impact of gut microbiota metabolites on macrophage phenotype and function, along with the underlying mechanisms associated with different metabolites produced by intestinal flora.
肠道菌群代谢产物通过多种途径影响宿主免疫反应，在免疫调节中发挥着关键作用。巨噬细胞作为一种固有免疫细胞，在趋化、吞噬、炎症反应和微生物清除中起着重要作用。不同的巨噬细胞表型具有不同的生物学功能，受多种因素和机制调控。肠道菌群测序和代谢组学的进展加深了人们对肠道菌群代谢产物如何影响巨噬细胞表型和功能的理解。这些代谢产物对巨噬细胞极化有不同影响，且影响机制各异。本研究总结了肠道微生物群代谢产物对巨噬细胞表型和功能的影响，以及与肠道菌群产生的不同代谢产物相关的潜在机制。
