Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing, 210023, People's Republic of China.
Appl Microbiol Biotechnol. 2022 Nov;106(21):6899-6913. doi: 10.1007/s00253-022-12197-2. Epub 2022 Oct 3.
Constipation is very pervasive all over the world. It is a common multifactorial gastrointestinal disease, and its etiology and pathomechanism are not completely clear. Now, increasing evidence shows that intestinal flora is closely related to constipation. Intestinal flora is the largest microbiota in the human body and has powerful metabolic functions. Intestinal flora can produce a variety of metabolites, such as bile acids, short-chain fatty acids, tryptophan metabolites, and methane, which have important effects on intestinal motility and secretion. The host can also monitor the intestinal flora and regulate gut dysbacteriosis in constipation. To explore the relationship between intestinal flora and host, the combination of multiomics technology has become the powerful and effective method. Furthermore, the homeostasis restoration of intestinal flora also provides a new strategy for the treatment of constipation. This review aims to explore the interaction between intestinal flora and host in constipation, which contributes to disclose the pathogenesis of constipation and the development of novel drugs for the treatment of constipation from the perspective of intestinal flora. KEY POINTS: • This review highlights the regulation of gut microbiota on the intestinal motility and secretion of host. • The current review gives an insight into the role of the host on the recognition and regulation of intestinal ecology under constipation. • The article also introduces some novel methods of current gut microbiota research and gut microbiota-based constipation therapies.
便秘在全球范围内非常普遍。它是一种常见的多因素胃肠道疾病，其病因和发病机制尚不完全清楚。现在，越来越多的证据表明，肠道菌群与便秘密切相关。肠道菌群是人体内最大的微生物群，具有强大的代谢功能。肠道菌群可以产生多种代谢物，如胆汁酸、短链脂肪酸、色氨酸代谢物和甲烷，这些代谢物对肠道蠕动和分泌有重要影响。宿主还可以监测肠道菌群并调节便秘中的肠道菌群失调。为了探索肠道菌群与宿主之间的关系，多组学技术的结合已成为一种强大而有效的方法。此外，肠道菌群的内稳态恢复也为便秘的治疗提供了新策略。本综述旨在探讨便秘中肠道菌群与宿主的相互作用，有助于从肠道菌群的角度揭示便秘的发病机制和开发治疗便秘的新药。
本综述强调了肠道微生物群对宿主肠道运动和分泌的调节作用。
本综述深入了解了宿主在便秘情况下对肠道生态的识别和调节作用。
本文还介绍了一些当前肠道微生物组研究和基于肠道微生物组的便秘治疗的新方法。
