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使用光学方法进行无创血红蛋白测量。

Non-invasive hemoglobin measurement using optical method.

作者信息

R Ranjith, S Priya, A S Kaviya Dharshini, J B Jeeva

机构信息

School of Electronics Engineering, VIT University, Vellore, India.

出版信息

Heliyon. 2024 Aug 3;10(15):e35777. doi: 10.1016/j.heliyon.2024.e35777. eCollection 2024 Aug 15.

Abstract

The measurement of Hemoglobin (Hb) by the non-invasive method is gaining popularity. The system, consisting of a photodiode is placed in between a Red (630 nm) and an IR (940 nm) LED, along with the signal conditioning circuits. 10 healthy male (8) and female (2) volunteers in the age group between 21 and 24 were recruited for this study. During measurement, the fingertip of a volunteer was placed on the measurement pad. Visible and IR lights are switched ON one after the other. The optical absorbance of the blood component in the arteries was detected by the photodiode using the reflectance method. The current generated was converted into voltage and was processed to remove the noise associated with the signal. From this, the concentration of Hb of the volunteers was determined. On the same day they were taken to the clinical laboratory and Hb values were obtained by the standard invasive method. Hemoglobin values obtained from the two methods were compared and an accuracy of 96.31 % and correlation coefficient value of 0.932405 was achieved. From the Bland -Altman plot, the results obtained are within the confidence interval of 95 %. The error of 3 % can be reduced further by employing sophisticated signal conditioning techniques. The proposed non-invasive method took only a few seconds to find the hemoglobin concentration than the invasive lab test. This method can accelerate the decision-making process in emergency situations.

摘要

通过非侵入性方法测量血红蛋白(Hb)正变得越来越流行。该系统由一个光电二极管组成,放置在红色(630纳米)和红外(940纳米)发光二极管之间,同时还有信号调节电路。本研究招募了10名年龄在21至24岁之间的健康男性(8名)和女性(2名)志愿者。在测量过程中,将一名志愿者的指尖放在测量垫上。可见光和红外光依次打开。光电二极管使用反射法检测动脉中血液成分的光吸收率。产生的电流被转换为电压,并进行处理以去除与信号相关的噪声。由此确定志愿者的Hb浓度。在同一天,他们被带到临床实验室,通过标准侵入性方法获得Hb值。比较了两种方法获得的血红蛋白值,准确率达到96.31%,相关系数值为0.932405。从布兰德-奥特曼图来看,所得结果在95%的置信区间内。通过采用先进的信号调节技术,3%的误差可以进一步降低。与侵入性实验室检测相比,所提出的非侵入性方法只需几秒钟就能找到血红蛋白浓度。这种方法可以加快紧急情况下的决策过程。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a79/11337058/0eb730c75738/gr1.jpg

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