College of Sports, Northwest Normal University, Lanzhou, China.
Institute of Medical Research, Northwestern Polytechnical University, Xi'an, China.
Front Endocrinol (Lausanne). 2024 Aug 7;15:1450328. doi: 10.3389/fendo.2024.1450328. eCollection 2024.
Osteoporosis, a systemic skeletal disorder marked by diminished bone mass and compromised bone microarchitecture, is becoming increasingly prevalent due to an aging population. The underlying pathophysiology of osteoporosis is attributed to an imbalance between osteoclast-mediated bone resorption and osteoblast-mediated bone formation. Osteoclasts play a crucial role in the development of osteoporosis through various molecular pathways, including the RANK/RANKL/OPG signaling axis, cytokines, and integrins. Notably, the calcium signaling pathway is pivotal in regulating osteoclast activation and function, influencing bone resorption activity. Disruption in calcium signaling can lead to increased osteoclast-mediated bone resorption, contributing to the progression of osteoporosis. Emerging research indicates that calcium-permeable channels on the cellular membrane play a critical role in bone metabolism by modulating these intracellular calcium pathways. Here, we provide an overview of current literature on the regulation of plasma membrane calcium channels in relation to bone metabolism with particular emphasis on their dysregulation during the progression of osteoporosis. Targeting these calcium channels may represent a potential therapeutic strategy for treating osteoporosis.
骨质疏松症是一种以骨量减少和骨微结构受损为特征的系统性骨骼疾病，由于人口老龄化，其发病率越来越高。骨质疏松症的潜在病理生理学归因于破骨细胞介导的骨吸收和成骨细胞介导的骨形成之间的失衡。破骨细胞通过多种分子途径在骨质疏松症的发展中起着至关重要的作用，包括 RANK/RANKL/OPG 信号轴、细胞因子和整合素。值得注意的是，钙信号通路在调节破骨细胞的激活和功能方面起着关键作用，影响骨吸收活性。钙信号通路的破坏可导致破骨细胞介导的骨吸收增加，从而促进骨质疏松症的进展。新的研究表明，细胞膜上的钙通透性通道通过调节这些细胞内钙通路，在骨代谢中起着关键作用。在这里，我们概述了与骨代谢有关的质膜钙通道调节的现有文献，特别强调了它们在骨质疏松症进展过程中的失调。靶向这些钙通道可能代表治疗骨质疏松症的一种潜在治疗策略。
