Souza Thamires, Dos Anjos Natalia, Kersul Isabel, Filho Emanuel Martins, Nunes Talyta, Barbosa Vivian
Veterinary Teaching Hospital, Federal University of Bahia, Salvador, Bahia State, Brazil.
In memoriam.
Vet Med (Praha). 2022 Feb 14;67(4):199-205. doi: 10.17221/138/2020-VETMED. eCollection 2022 Apr.
The aim of this study was to compare the effects of midazolam-ketamine alone or in combination with dexmedetomidine or tramadol in a constant rate infusion (CRI) on the minimum infusion rate (MIR) of propofol and the cardiorespiratory function in cats undergoing an ovariohysterectomy (OH). This was a prospective, randomised, blinded clinical study. Twenty-four healthy female mixed-breed cats were premedicated with ketamine and midazolam. Propofol was used for the induction and maintenance of the anaesthesia (starting at 18 mg/kg/h). Cats were assigned to groups ( = 8) to receive one of the following intravenous treatments: midazolam-ketamine group (MKG; ketamine 0.6 mg/kg/h); midazolam-ketamine-dexmedetomidine group [MKDG; ketamine 0.6 mg/kg/h and dexmedetomidine loading dose (LD) 1 mg/kg, CRI 1 mg/kg/h)] or midazolam-ketamine-tramadol group [MKTG; ketamine 0.6 mg/kg/h and tramadol (LD 2 mg/kg, CRI 1 mg/kg/h)]. During the OH, the propofol infusion was adjusted based on the clinical signs to maintain adequate anaesthetic depth. Selected variables were measured before (T0) and after (T1) the anaesthesia induction and during six surgical time points (T2-T7). The mean arterial pressure was higher and the heart rate was lower in MKDG at T1 (than in MKG and MKTG). The mean ± SD MIR of propofol were 17.4 ± 3.2, 15.0 ± 2.8 and 12.6 ± 3.5 mg/kg/h for MKG, MKTG, and MKDG, respectively. We conclude that, compared to midazolam-ketamine alone, midazolam-ketamine-tramadol and midazolam-ketamine-dexmedetomidine reduced the MRI of propofol by 13.8% and 27.5%, respectively, without significant changes in the selected indicators.
本研究的目的是比较咪达唑仑 - 氯胺酮单独使用或与右美托咪定或曲马多联合持续静脉输注（CRI）对接受卵巢子宫切除术（OH）的猫丙泊酚最低输注速率（MIR）和心肺功能的影响。这是一项前瞻性、随机、盲法临床研究。24只健康雌性混种猫用氯胺酮和咪达唑仑进行术前用药。丙泊酚用于诱导和维持麻醉（起始剂量为18mg/kg/h）。将猫分为几组（每组 = 8只），接受以下静脉治疗之一：咪达唑仑 - 氯胺酮组（MKG；氯胺酮0.6mg/kg/h）；咪达唑仑 - 氯胺酮 - 右美托咪定组[MKDG；氯胺酮0.6mg/kg/h和右美托咪定负荷剂量（LD）1mg/kg，CRI 1mg/kg/h]或咪达唑仑 - 氯胺酮 - 曲马多组[MKTG；氯胺酮0.6mg/kg/h和曲马多（LD 2mg/kg，CRI 1mg/kg/h）]。在OH手术期间，根据临床体征调整丙泊酚输注以维持足够的麻醉深度。在麻醉诱导前（T0）和后（T1）以及六个手术时间点（T2 - T7）测量选定变量。在T1时，MKDG组的平均动脉压较高，心率较低（比MKG组和MKTG组）。MKG组、MKTG组和MKDG组丙泊酚的平均±标准差MIR分别为17.4±3.2、15.0±2.8和12.6±3.5mg/kg/h。我们得出结论，与单独使用咪达唑仑 - 氯胺酮相比，咪达唑仑 - 氯胺酮 - 曲马多和咪达唑仑 - 氯胺酮 - 右美托咪定分别使丙泊酚的MRI降低了13.8%和27.5%，所选指标无显著变化。
