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镓标记的纤维连接蛋白激活肽正电子发射断层扫描/计算机断层扫描（Ga-FAPI PET/CT）与氟代脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（F-FDG PET/CT）：鉴别一例乳腺癌/获得性免疫缺陷综合征患者的转移性疾病和反应性淋巴结

Ga-FAPI PET/CT versus F-FDG PET/CT: Differentiating Metastatic Disease and Reactive Lymph Nodes in a Case of Carcinoma of Breast/Acquired Immunodeficiency Syndrome.

作者信息

Gunasekaran Gopinathraj, Amalachandran Jaykanth

机构信息

Department of Nuclear Medicine, PET-CT and Theranostics, Apollo Proton Cancer Centre, Chennai, Tamil Nadu, India.

出版信息

World J Nucl Med. 2024 Jun 14;23(3):217-219. doi: 10.1055/s-0044-1787718. eCollection 2024 Sep.

DOI:10.1055/s-0044-1787718
PMID:39170836
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11335381/
Abstract

Gallium-68 ( Ga)-fibroblast activation protein inhibitor (FAPI) positron emission tomography (PET) images the cancer-associated fibroblast that forms a vital component of the tumor microenvironment. It is known that Ga-FAPI PET can aid in differentiating reactive lymph nodes from metastatic lymph nodes. F-fluorodeoxyglucose (FDG) PET/computed tomography (CT) is still the most commonly used PET radiopharmaceutical in the evaluation of a wide range of malignancies including breast carcinoma. Reactive lymph nodes may also show FDG uptake which can hinder optimal assessment for metastatic involvement. We report an interesting case of invasive ductal carcinoma of the right breast with associated World Health Organization clinical stage I acquired immunodeficiency syndrome for which F-FDG PET/CT and Ga-FAPI PET/CT were done.

摘要

镓-68（⁶⁸Ga）-成纤维细胞活化蛋白抑制剂（FAPI）正电子发射断层扫描（PET）可对构成肿瘤微环境重要组成部分的癌症相关成纤维细胞进行成像。已知⁶⁸Ga-FAPI PET有助于鉴别反应性淋巴结和转移性淋巴结。¹⁸F-氟脱氧葡萄糖（FDG）PET/计算机断层扫描（CT）仍是评估包括乳腺癌在内的多种恶性肿瘤时最常用的PET放射性药物。反应性淋巴结也可能显示FDG摄取，这可能会妨碍对转移累及情况的最佳评估。我们报告了一例有趣的右乳腺浸润性导管癌病例，该病例伴有世界卫生组织临床I期获得性免疫缺陷综合征，为此进行了¹⁸F-FDG PET/CT和⁶⁸Ga-FAPI PET/CT检查。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f26/11335381/554674d1476d/10-1055-s-0044-1787718-i2430002-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f26/11335381/7c18d283cf54/10-1055-s-0044-1787718-i2430002-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f26/11335381/554674d1476d/10-1055-s-0044-1787718-i2430002-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f26/11335381/7c18d283cf54/10-1055-s-0044-1787718-i2430002-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f26/11335381/554674d1476d/10-1055-s-0044-1787718-i2430002-2.jpg

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本文引用的文献

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Clin Nucl Med. 2023 Sep 1;48(9):e420-e430. doi: 10.1097/RLU.0000000000004751. Epub 2023 Jun 23.
2
FAPI PET/CT in infectious, inflammatory, and rheumatological diseases: "watch it like a hawk" or "one swallow does not make a summer"?FAPI PET/CT在感染性、炎症性和风湿性疾病中的应用：“密切关注”还是“一燕不成夏”？
Eur J Nucl Med Mol Imaging. 2023 Jun;50(7):1848-1850. doi: 10.1007/s00259-023-06179-3.
3
PET/CT with Fibroblast Activation Protein Inhibitors in Breast Cancer: Diagnostic and Theranostic Application-A Literature Review.
正电子发射断层显像/计算机断层扫描联用成纤维细胞活化蛋白抑制剂在乳腺癌中的应用：诊断与诊疗一体化应用——文献综述
Cancers (Basel). 2023 Jan 31;15(3):908. doi: 10.3390/cancers15030908.
4
Differentiation of Reactive Lymph Nodes and Tumor Metastatic Lymph Nodes With 68Ga-FAPI PET/CT in a Patient With Squamous Cell Lung Cancer.68Ga-FAPI PET/CT 区分肺鳞癌患者反应性淋巴结与肿瘤转移淋巴结。
Clin Nucl Med. 2022 May 1;47(5):458-461. doi: 10.1097/RLU.0000000000003998.
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68Ga-FAPI PET/CT Distinguishes the Reactive Lymph Nodes From Tumor Metastatic Lymph Nodes in a Patient With Nasopharyngeal Carcinoma.68Ga-FAPI PET/CT 可区分鼻咽癌患者反应性淋巴结与肿瘤转移淋巴结。
Clin Nucl Med. 2022 Apr 1;47(4):367-368. doi: 10.1097/RLU.0000000000003939.
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Simultaneous FAPI PET/MRI Targeting the Fibroblast-Activation Protein for Breast Cancer.同时靶向成纤维细胞激活蛋白的 FAPI PET/MRI 用于乳腺癌。
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