Buckley C D, Pilling D, Lord J M, Akbar A N, Scheel-Toellner D, Salmon M
Division of Immunity and Infection, MRC Centre for Immune Regulation, University of Birmingham, Birmingham, UK B15 2TT.
Trends Immunol. 2001 Apr;22(4):199-204. doi: 10.1016/s1471-4906(01)01863-4.
Fibroblasts are important sentinel cells in the immune system and, here, it is proposed that these cells play a critical role in the switch from acute inflammation to adaptive immunity and tissue repair. It is suggested that chronic inflammation occurs because of disordered fibroblast behaviour in which failure to switch off their inflammatory programme leads to the inappropriate survival and retention of leukocytes within inflamed tissue.
成纤维细胞是免疫系统中重要的前哨细胞，本文提出这些细胞在从急性炎症向适应性免疫和组织修复的转变过程中发挥关键作用。有人认为，慢性炎症的发生是由于成纤维细胞行为紊乱，即未能关闭其炎症程序，导致白细胞在炎症组织中不适当的存活和滞留。
