孤立功能肾减弱雄性而非雌性大鼠对血管紧张素II的肾血流动力学反应。
Solitary Functioning Kidneys Attenuate Renal Hemodynamics Responses to Angiotensin II in Male But Not in Female Rats.
作者信息
Pezeshki Zahra, Nematbakhsh Mehdi
机构信息
Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran.
Water and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
出版信息
Int J Prev Med. 2024 Jul 17;15:19. doi: 10.4103/ijpvm.ijpvm_195_23. eCollection 2024.
BACKGROUNDS
People with solitary functioning kidneys (SFK) are prone to renal failure with time. Accordingly, local renin angiotensin system (RAS) and renal functions in subjects with SFK may act differently compared to normal condition. This study was designed to determine the renal hemodynamics responses to angiotensin II (Ang. II) in SFK male and female rats.
METHODS
Fifty to sixty-day-old male and female Wistar rats were subjected to unilateral renal artery obstruction, and 28 days later basal renal hemodynamic responses to Ang. II were examined in SFK groups compared to sham groups.
RESULTS
The findings indicated lower renal vascular resistance (RVR) and renal blood flow (RBF) responses to Ang. II in male SFK compared to sham group. Such observation was not seen in female animals.
CONCLUSIONS
An increase in renal metabolism due to hyperfunction, especially in SFK male rats, may cause a decrease in RVR. Moreover, the lower RBF response to Ang. II may be related to alteration to Ang. II receptors in the remnant kidneys in SFK rats.
背景
孤立功能性肾（SFK）患者随着时间推移易发生肾衰竭。因此，与正常情况相比，SFK患者的局部肾素血管紧张素系统（RAS）和肾功能可能表现不同。本研究旨在确定SFK雄性和雌性大鼠对血管紧张素II（Ang. II）的肾血流动力学反应。
方法
对50至60日龄的雄性和雌性Wistar大鼠进行单侧肾动脉阻塞，28天后，与假手术组相比，检测SFK组对Ang. II的基础肾血流动力学反应。
结果
研究结果表明，与假手术组相比，雄性SFK对Ang. II的肾血管阻力（RVR）和肾血流量（RBF）反应较低。在雌性动物中未观察到这种现象。
结论
功能亢进导致的肾代谢增加，尤其是在SFK雄性大鼠中，可能会导致RVR降低。此外，对Ang. II的RBF反应较低可能与SFK大鼠残余肾中Ang. II受体的改变有关。
Zotero 插件