Dimayuga Paul C, Chyu Kuang-Yuh, Zhao Xiaoning, Zhou Jianchang, Lio Nicole Wai Man, Chernomordik Fernando, Berman Daniel, Shah Prediman K, Cercek Bojan
Oppenheimer Atherosclerosis Research Center, Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Departments of Imaging and Medicine and Burns and Allen Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
JACC Basic Transl Sci. 2024 Jul 22;9(7):877-887. doi: 10.1016/j.jacbts.2024.04.012. eCollection 2024 Jul.
The cathelicidin antimicrobial peptide LL-37 is a self-antigen in neutrophil extracellular traps that provokes autoantibody responses in autoimmune/autoinflammatory conditions. LL-37 immunoglobulin (Ig) G autoantibody levels were measured in subjects with and without atherosclerotic cardiovascular disease assessed using the coronary artery calcium score, in patients who had a future myocardial infarction and in a cohort of acute coronary syndrome (ACS) patients. LL-37 IgG levels were not associated with coronary artery calcium score, but future myocardial infarction patients had significantly higher LL-37 IgG at baseline. Reduced LL-37 IgG in ACS was associated with increased LL-37 IgG-immune complex. ACS plasma increased activated CD62P+ platelets from healthy donors mediated in part by LL-37 IgG-immune complexes and platelet Fc gamma receptor 2a.
杀菌通透性增加蛋白抗菌肽LL-37是中性粒细胞胞外诱捕网中的一种自身抗原，在自身免疫/自身炎症性疾病中可引发自身抗体反应。在通过冠状动脉钙化评分评估的有或无动脉粥样硬化性心血管疾病的受试者、未来发生心肌梗死的患者以及一组急性冠状动脉综合征（ACS）患者中，检测了LL-37免疫球蛋白（Ig）G自身抗体水平。LL-37 IgG水平与冠状动脉钙化评分无关，但未来发生心肌梗死的患者在基线时LL-37 IgG显著更高。ACS患者中LL-37 IgG降低与LL-37 IgG免疫复合物增加有关。ACS血浆增加了健康供体的活化CD62P+血小板，这部分是由LL-37 IgG免疫复合物和血小板Fcγ受体2a介导的。
