Wei Wu-Jie, Hong Ya-Li, Deng Yi, Wang Guan-Liang, Qiu Jiang-Tao, Pan Fang
Department of Oncology, People's Hospital of Chongqing Hechuan, Chongqing 401520, China.
Department of Cardiovascular, People's Hospital of Chongqing Hechuan, Chongqing 401520, China.
World J Gastrointest Oncol. 2024 Aug 15;16(8):3397-3409. doi: 10.4251/wjgo.v16.i8.3397.
Hepatocyte growth factor (HGF) and its receptor, c-Met, play important roles in the occurrence, development, and treatment of gastric cancer (GC). This review explored the function of the HGF/c-Met signaling pathway in GC and its potential targeted therapeutic mechanisms. As one of the most common malignant tumors worldwide, GC has a complex pathogenesis and limited therapeutic options. Therefore, a thorough understanding of the molecular mechanism of GC is very important for the development of new therapeutic methods. The HGF/c-Met signaling pathway plays an important role in the proliferation, migration, and invasion of GC cells and has become a new therapeutic target. This review summarizes the current research progress on the role of HGF/c-Met in GC and discusses targeted therapeutic strategies targeting this signaling pathway, providing new ideas and directions for the treatment of GC.
肝细胞生长因子（HGF）及其受体c-Met在胃癌（GC）的发生、发展和治疗中发挥着重要作用。本综述探讨了HGF/c-Met信号通路在胃癌中的功能及其潜在的靶向治疗机制。作为全球最常见的恶性肿瘤之一，胃癌发病机制复杂，治疗选择有限。因此，深入了解胃癌的分子机制对于开发新的治疗方法非常重要。HGF/c-Met信号通路在胃癌细胞的增殖、迁移和侵袭中起重要作用，已成为一个新的治疗靶点。本综述总结了目前关于HGF/c-Met在胃癌中作用的研究进展，并讨论了针对该信号通路的靶向治疗策略，为胃癌的治疗提供新的思路和方向。
