Wu Minmin, Song Wenjing, Teng Lili, Li Jinting, Liu Jiayu, Ma Hanwen, Zhang Ge, Zhang Jiongliang, Chen Qiuxin
Department of Rehabilitation Medicine, Heilongjiang University of Chinese Medicine, Harbin, China.
The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, China.
Front Cell Neurosci. 2024 Aug 7;18:1405782. doi: 10.3389/fncel.2024.1405782. eCollection 2024.
Traumatic brain injury (TBI) occurs when external physical forces impact the brain, potentially causing long-term issues such as post-traumatic stress disorders and cognitive and physical dysfunctions. The diverse nature of TBI pathology and treatment has led to a rapid acceleration in research on its biological mechanisms over the past decade. This surge presents challenges in assessing, managing, and predicting outcomes for TBI cases. Despite the development and testing of various therapeutic strategies aimed at mitigating neurological decline after TBI, a definitive cure for these conditions remains elusive. Recently, a growing focus has been on preclinical research investigating acupuncture as a potential treatment method for TBI sequelae. Acupuncture, being a cost-effective non-pharmacological therapy, has demonstrated promise in improving functional outcomes after brain injury. However, the precise mechanisms underlying the anticipated improvements induced by acupuncture remain poorly understood. In this study, we examined current evidence from animal studies regarding acupuncture's efficacy in improving functional outcomes post-TBI. We also proposed potential biological mechanisms, such as glial cells (microglia astrocytes), autophagy, and apoptosis. This information will deepen our understanding of the underlying mechanisms through which acupuncture exerts its most beneficial effects post-TBI, assisting in forming new clinical strategies to maximize benefits for these patients.
外伤性脑损伤（TBI）是指外部物理力量撞击大脑时发生的情况，可能会导致诸如创伤后应激障碍以及认知和身体功能障碍等长期问题。在过去十年中，TBI病理学和治疗方法的多样性促使其生物学机制的研究迅速加速。这种激增给TBI病例的评估、管理和预后预测带来了挑战。尽管已经开发并测试了各种旨在减轻TBI后神经功能衰退的治疗策略，但这些病症的最终治愈方法仍然难以捉摸。最近，越来越多的焦点集中在临床前研究上，该研究将针灸作为TBI后遗症的一种潜在治疗方法进行调查。针灸作为一种具有成本效益的非药物疗法，已显示出在改善脑损伤后功能结局方面的前景。然而，针灸所带来的预期改善背后的确切机制仍知之甚少。在本研究中，我们研究了动物研究中有关针灸改善TBI后功能结局疗效的现有证据。我们还提出了潜在的生物学机制，如神经胶质细胞（小胶质细胞、星形胶质细胞）、自噬和细胞凋亡。这些信息将加深我们对针灸在TBI后发挥最有益作用的潜在机制的理解，有助于形成新的临床策略，为这些患者带来最大益处。
