Beckman Laser Institute Korea, Dankook University, Cheonan, Republic of Korea.
Laser Translational Clinical Trial Center, Dankook University Hospital, Cheonan, Republic of Korea.
J Cosmet Laser Ther. 2024 Jan-Jun;26(1-4):54-60. doi: 10.1080/14764172.2024.2375384. Epub 2024 Aug 22.
Fractional ablative resurfacing techniques are preferred treatments for facial rejuvenation of aged skin. This study was performed to investigate the cutaneous effects of using a fractional picosecond laser at 1064 nm with a diffractive lens.
The penetration depth according to the location of the handpiece tip was evaluated using an acrylic panel. Laser induced optical breakdown (LIOB) and cutaneous damage were observed after hematoxylin and eosin staining in guinea pigs. Collagen formation was evaluated using Victoria staining, Masson's trichrome (MT) staining, and immunohistochemical staining for collagen type III.
The penetration depth for LEVEL 1 was 499.98-935.23 μm (average: 668.75 ± 182.84 μm); the LIOB cavity area was 1664.17 ± 650.52 μm. The penetration depth of LEVEL 2 was 257.12-287.38 μm (average: 269.77 ± 14.55 μm) with an LIOB cavity area of 1335.85 ± 214.41 μm. At LEVEL 3, that was 36.17-53.69 μm (average: 52.15 ± 20.81 μm) and the LIOB cavity area was 1312.67 ± 1069.12 μm. No epidermal tissue damage was observed and collagen formation was observed from day 14 under all conditions.
Diffractive optical element (DOE) lens arranged laser treatment system controlled the position of LIOB occurrence and an irradiating area.
分碎性表皮再生术是治疗老化皮肤的首选方法。本研究旨在探讨使用 1064nm 分碎性皮秒激光和衍射透镜对面部年轻化的皮肤效果。
使用亚克力板评估根据手柄尖端位置的穿透深度。在豚鼠中，通过苏木精和伊红染色观察激光诱导光击穿（LIOB）和皮肤损伤。使用维多利亚染色、马松三色（MT）染色和 III 型胶原免疫组化染色评估胶原蛋白的形成。
LEVEL 1 的穿透深度为 499.98-935.23μm（平均：668.75±182.84μm）；LIOB 腔面积为 1664.17±650.52μm。LEVEL 2 的穿透深度为 257.12-287.38μm（平均：269.77±14.55μm），LIOB 腔面积为 1335.85±214.41μm。在 LEVEL 3，穿透深度为 36.17-53.69μm（平均：52.15±20.81μm），LIOB 腔面积为 1312.67±1069.12μm。在所有条件下，均未观察到表皮组织损伤，并且在第 14 天观察到胶原蛋白的形成。
衍射光学元件（DOE）透镜排列的激光治疗系统可控制 LIOB 发生位置和照射面积。
