Department of Dermatology, Hallym University Sacred Heart Hospital, Anyang, Korea.
Seoul Hong Skin Clinic, Seoul, Korea.
J Cosmet Dermatol. 2024 Jul;23(7):2411-2419. doi: 10.1111/jocd.16275. Epub 2024 Mar 18.
Indocyanine green (ICG) exhibits robust absorption near 800 nm.
To examine the clinical effects of combining ICG with a 785 nm picosecond laser for treating photo-aged skin.
PATIENT/METHODS: A 785 nm 600 picosecond laser was used on the facial area of 16 female patients with Fitzpatrick skin type III and IV (mean age: 58.44 ± 5.24 years) after applying 0.0125% ICG cream. A total of 3000 shots were administered in diffractive optical element mode at a pulse energy of 200 mJ and frequency of 10 Hz. Hyperpigmented lesions were treated using the Zoom handpiece set at a spot size of 3-4 mm, pulse energy of 60-120 mJ, and frequency of 3-7 Hz. Patients underwent five sessions of treatment at intervals of 1-2 weeks. Wrinkles, pores and pigmented lesions were assessed at the initial assessment and 4 weeks after the final treatment using the Modified Fitzpatrick Wrinkle Scale and 10-point visual analog scale, respectively. Skin biopsy of the postauricular area was performed on two consenting patients.
Significant improvements in wrinkles (p = 0.02), pores (p = 0.034), and hyperpigmentation (p = 0.036) were observed, along with increased patient subjective improvement. Adverse effects were transient and well-tolerated. Hematoxylin and eosin and Masson's trichrome staining revealed increased and thickened dermal collagen fibers. Immunohistochemical staining revealed increased expression of collagen I and III throughout the papillary and upper reticular dermis, along with diffuse increase of STRO-1 in the dermis.
The combined application of a 785 nm picosecond laser and ICG yielded promising clinical outcomes for treating photo-aged skin in Asian patients with Fitzpatrick skin type III and IV.
吲哚菁绿（ICG）在近 800nm 处表现出强烈的吸收。
研究将 ICG 与 785nm 皮秒激光联合应用于治疗光老化皮肤的临床效果。
患者/方法：在 16 名 III 型和 IV 型（平均年龄：58.44±5.24 岁）Fitzpatrick 皮肤类型的女性患者面部应用 0.0125%ICG 霜后，使用 785nm600ps 皮秒激光。在漫射光学元件模式下，以 200mJ 的脉冲能量和 10Hz 的频率共进行 3000 次射击。使用 Zoom 手柄以 3-4mm 的光斑大小、60-120mJ 的脉冲能量和 3-7Hz 的频率治疗色素沉着病变。患者在 1-2 周的间隔内进行五次治疗。在初始评估和最后一次治疗后 4 周，使用改良的 Fitzpatrick 皱纹量表和 10 分视觉模拟量表分别评估皱纹、毛孔和色素沉着病变。对两名同意的患者的耳后区域进行皮肤活检。
观察到皱纹（p=0.02）、毛孔（p=0.034）和色素沉着（p=0.036）显著改善，同时患者主观改善增加。不良反应是短暂的且耐受良好。苏木精和伊红及 Masson 三色染色显示真皮胶原纤维增多和增厚。免疫组织化学染色显示在上皮和网状真皮的整个乳头层和上层中，I 型和 III 型胶原表达增加，真皮中 STRO-1 弥漫增加。
785nm 皮秒激光与 ICG 的联合应用为亚洲 III 型和 IV 型 Fitzpatrick 皮肤类型的光老化患者的皮肤治疗提供了有前景的临床结果。
