Department of Chemical, Pharmaceutical and Agricultural Sciences (Docpas), University of Ferrara, University of Ferrara, Ferrara, Italy.
Biotechnology InterUniversity Consortium (C.I.B.), Ferrara Section, University of Ferrara, Ferrara, Italy.
Expert Opin Drug Deliv. 2024 Aug;21(8):1191-1211. doi: 10.1080/17425247.2024.2391473. Epub 2024 Sep 11.
Wounds, resulting from traumas, surgery, burns or diabetes, are important medical problems due to the complexity of wound healing process regarding healing times and healthcare costs. Nanosystems have emerged as promising candidates in this field thank to their properties and versatile applications in drugs delivery.
Lipid-based nanosystems (LBN) are described for wound treatment, highlighting their different behaviors when interacting with the cutaneous tissue. The role of nanosystems in delivering mostly natural compounds on skin as well as the technological and engineering strategies to increase their efficiency in wound healing effect are reviewed. Finally, and studies are reported.
LBN have shown promise in addressing the challenges of wound healing as they can improve the stability of drugs used in wound therapy, leading to higher efficacy and fewer adverse effects as compared to traditional formulations. LBNs being involved in the inflammatory and proliferation stages of the wound healing process, enable the modification of wound healing through multiple ways. In addition, the use of new technologies, including 3D bioprinting and photobiomodulation, may lead to potential breakthroughs in wound healing. This would provide clinicians with more potent forms of therapy for wound healing.
创伤、手术、烧伤或糖尿病导致的伤口是一个重要的医学问题，这是由于伤口愈合过程的复杂性，涉及愈合时间和医疗保健成本。由于其特性和在药物输送方面的多种应用，纳米系统已成为该领域有前途的候选者。
脂质基纳米系统（LBN）被描述用于伤口治疗，突出了它们在与皮肤组织相互作用时的不同行为。综述了纳米系统在皮肤递送主要天然化合物方面的作用，以及提高其在伤口愈合效果方面效率的技术和工程策略。最后，报告了 和 研究。
LBN 在解决伤口愈合挑战方面显示出了前景，因为与传统制剂相比，它们可以提高用于伤口治疗的药物的稳定性，从而提高疗效，减少不良反应。LBN 参与伤口愈合的炎症和增殖阶段，能够通过多种方式改变伤口愈合过程。此外，包括 3D 生物打印和光生物调节在内的新技术的使用可能会引领伤口愈合领域的潜在突破。这将为临床医生提供更有效的伤口愈合治疗方法。
