Oyarzun-Ampuero Felipe, Vidal Alejandra, Concha Miguel, Morales Javier, Orellana Sandra, Moreno-Villoslada Ignacio
Departamento de Ciencias y Tecnología Farmacéuticas, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago, Chile.
Instituto de Ciencias Químicas, Facultad de Ciencias, Universidad Austral de Chile, Isla Teja, Casilla 567, Valdivia, Chile.
Curr Pharm Des. 2015;21(29):4329-41. doi: 10.2174/1381612821666150901104601.
The treatment of skin wounds represents an important research area due to the important physiological and aesthetic role of this tissue. During the last years, nanoparticles have emerged as important platforms to treat skin wounds. Silver, gold, and copper nanoparticles, as well as titanium and zinc oxide nanoparticles, have shown potential therapeutic effects on wound healing. Due to their specific characteristics, nanoparticles such as nanocapsules, polymersomes, solid lipid nanoparticles, and polymeric nanocomplexes are ideal vehicles to improve the effect of drugs (antibiotics, growth factors, etc.) aimed at wound healing. On the other hand, if active excipients are added during the formulation, such as hyaluronate or chitosan, the nanomedicine could significantly improve its potential. In addition, the inclusion of nanoparticles in different pharmaceutical materials may enhance the beneficial effects of the formulations, and allow achieving a better dose control. This paper aims at reviewing significant findings in the area of nanoparticles and wound treatment. Among the reviewed topics, we underline formulations comprising inorganic, polymeric, surfactant self-assembled, and lipid nanosystems. Among the drugs included in the nanoformulations, the paper refers to antibiotics, natural extracts, proteins, and growth factors, among others. Finally, the paper also addresses nanoparticles embedded in secondary vehicles (fibers, dressings, hydrogels, etc.) that could improve their application and/or upgrade the release profile of the active.
由于皮肤组织具有重要的生理和美学作用，皮肤伤口的治疗是一个重要的研究领域。在过去几年中，纳米颗粒已成为治疗皮肤伤口的重要平台。银、金和铜纳米颗粒，以及钛和氧化锌纳米颗粒，已显示出对伤口愈合的潜在治疗作用。由于其特定特性，诸如纳米胶囊、聚合物囊泡、固体脂质纳米颗粒和聚合物纳米复合物等纳米颗粒是改善旨在促进伤口愈合的药物（抗生素、生长因子等）效果的理想载体。另一方面，如果在制剂过程中添加活性辅料，如透明质酸盐或壳聚糖，纳米药物可显著提高其潜力。此外，将纳米颗粒包含在不同的药物材料中可能会增强制剂的有益效果，并实现更好的剂量控制。本文旨在综述纳米颗粒与伤口治疗领域的重要发现。在综述的主题中，我们强调了包含无机、聚合物、表面活性剂自组装和脂质纳米系统的制剂。在纳米制剂中包含的药物方面，本文提到了抗生素、天然提取物、蛋白质和生长因子等。最后，本文还讨论了嵌入二级载体（纤维、敷料、水凝胶等）中的纳米颗粒，这些纳米颗粒可以改善其应用和/或提升活性成分的释放特性。
