Goldberg R B, Rabin D, Alexander A N, Doelle G C, Getz G S
J Clin Endocrinol Metab. 1985 Jan;60(1):203-7. doi: 10.1210/jcem-60-1-203.
Men have lower high density lipoprotein (HDL) and higher low density lipoprotein (LDL) levels than women. To dynamically evaluate the role of endogenous testosterone on the lipoprotein profile, eight normal men received a long-acting gonadotropin releasing hormone analog (LHRHA) for 10 weeks by SC injection. Plasma testosterone levels were acutely lowered below 1 ng/ml after 4 weeks of LHRHA treatment and remained depressed at this level for the duration of administration of the analog. There were prompt increases in total cholesterol [baseline vs. peak (milligrams per dl) mean +/- SEM, 177 +/- 18 vs. 208 +/- 22; P less than 0.005], apoprotein B (apo B; 69 +/- 12 vs. 97 +/- 13; P less than 0.05), HDL-cholesterol (23 +/- 2 vs. 33 +/- 2; P less than 0.005), and apo A-I (80 +/- 7 vs. 112 +/- 5; P less than 0.005), but not in apo A-II (40 +/- 3 vs. 40 +/- 4; P = NS) levels. The peaks occurred after 10 weeks of treatment and were followed by a fall in these values after discontinuing LHRHA. These changes were largely prevented in a second study (six men) in which LHRHA was administered together with im testosterone enanthate, which was given every 2 weeks. These results show that suppression of endogenous testosterone leads to increases in HDL and LDL, demonstrating that testosterone has an important effect on lipoprotein metabolism and plays a key role in defining the lipoprotein profile in men.
男性的高密度脂蛋白（HDL）水平低于女性，而低密度脂蛋白（LDL）水平则高于女性。为动态评估内源性睾酮对脂蛋白谱的作用，8名正常男性通过皮下注射接受了10周的长效促性腺激素释放激素类似物（LHRHA）治疗。LHRHA治疗4周后，血浆睾酮水平急剧降至1 ng/ml以下，并在类似物给药期间一直维持在该水平。总胆固醇[基线值与峰值（毫克/分升），平均值±标准误，177±18 vs. 208±22；P<0.005]、载脂蛋白B（apo B；69±12 vs. 97±13；P<0.05）、HDL-胆固醇（23±2 vs. 33±2；P<0.005）和apo A-I（80±7 vs. 112±5；P<0.005）水平迅速升高，但apo A-II水平（40±3 vs. 40±4；P=无显著性差异）未升高。峰值出现在治疗10周后，停用LHRHA后这些值下降。在第二项研究（6名男性）中，这些变化在很大程度上得到了预防，在该研究中，LHRHA与每2周注射一次的庚酸睾酮同时给药。这些结果表明，内源性睾酮的抑制导致HDL和LDL升高，表明睾酮对脂蛋白代谢有重要影响，并在确定男性脂蛋白谱中起关键作用。
