Gupta R S, Dixit V P
Department of Zoology, University of Rajasthan, Jaipur, India.
Z Ernahrungswiss. 1988 Dec;27(4):236-43. doi: 10.1007/BF02019512.
Cholesterol fed to male rats and rabbits for 120 days impaired testicular function. The production of secondary spermatocytes in rats and rabbits was reduced by 26.1% and 46.9%, respectively. There was significant reduction in spermatid cell population, seminiferous tubules, and Leydig's cell nuclear dimensions. In rats aortic endothelium showed some alterations while in rabbits full-blown atherosclerotic plaque containing a necrotic core and a proliferative fibrous cap was found. Total cholesterol, triglycerides and phospholipids of the testes were increased whereas, testicular glycogen was significantly reduced. Three- and sevenfold increases were noticed in the serum cholesterol levels of rats and rabbits. The LDL cholesterol values were increased while the HDL cholesterol/Total cholesterol ratio was significantly decreased (P less than 0.001). It is concluded that hypercholesterolemia affects the testicular function and aortic endothelium.
给雄性大鼠和兔子喂食胆固醇120天会损害睾丸功能。大鼠和兔子的次级精母细胞生成分别减少了26.1%和46.9%。精子细胞数量、生精小管和睾丸间质细胞核尺寸均显著减小。在大鼠中，主动脉内皮出现了一些改变，而在兔子中发现了含有坏死核心和增殖性纤维帽的成熟动脉粥样硬化斑块。睾丸的总胆固醇、甘油三酯和磷脂增加，而睾丸糖原显著减少。大鼠和兔子的血清胆固醇水平分别升高了3倍和7倍。低密度脂蛋白胆固醇值升高，而高密度脂蛋白胆固醇/总胆固醇比值显著降低（P小于0.001）。结论是高胆固醇血症会影响睾丸功能和主动脉内皮。
