Goldman G A, Schoenfeld A, Ovadia J, Fisch B
Department of Obstetrics and Gynecology, Beilinson Medical Center, Petah-Tikva, Israel.
J Assist Reprod Genet. 1996 Mar;13(3):223-7. doi: 10.1007/BF02065940.
There is increasing evidence regarding the correlation between the risk of death from cardiovascular disease and low levels of HDL-cholesterol or high plasma concentrations of LDL-cholesterol, total cholesterol, and triglycerides. Gonadotropin releasing hormone (GhRH) analogues are widely used in assisted reproduction programs. Therefore, it seems important to evaluate possible changes in serum lipoprotein levels following treatment with these compounds.
Our purpose was to assess possible lipoprotein changes following administration of the long-acting GnRH analogue, D-Trp6 luteinizing hormone-releasing hormone (LH-RH).
Serum levels of cholesterol, HDL-cholesterol, LDL-cholesterol, and triglicerydes were determined before and after 6 weeks of treatment.
No significant changes in either cholesterol or HDL-cholesterol, LDL-cholesterol, or triglicerydes following treatment with D-Trp6 LH-RH were demonstrated in the group of 25 patients investigated.
Short-term use of D-Trp6 LH-RH is not associated with any significant change in plasma lipid levels. Further studies are still required with patients undergoing repeated treatment cycles, especially those who exhibit elevated pretreatment plasma lipid levels, to confirm the long-term safety of GnRH analogues with respect to lipid metabolism.
越来越多的证据表明心血管疾病死亡风险与高密度脂蛋白胆固醇水平低或血浆低密度脂蛋白胆固醇、总胆固醇和甘油三酯浓度高之间存在关联。促性腺激素释放激素（GnRH）类似物广泛应用于辅助生殖项目。因此，评估这些化合物治疗后血清脂蛋白水平的可能变化似乎很重要。
我们的目的是评估长效GnRH类似物D-色氨酸6促黄体生成素释放激素（LH-RH）给药后脂蛋白的可能变化。
在治疗6周前后测定胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇和甘油三酯的血清水平。
在接受调查的25例患者组中，用D-色氨酸6 LH-RH治疗后，胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇或甘油三酯均无显著变化。
短期使用D-色氨酸6 LH-RH与血浆脂质水平的任何显著变化无关。仍需要对接受重复治疗周期的患者，特别是那些治疗前血浆脂质水平升高的患者进行进一步研究，以证实GnRH类似物在脂质代谢方面的长期安全性。
