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具有优异生物降解性和细胞生长性能的生物基聚己内酯纳米纤维,用于可持续的医疗保健纺织品。

Biobased Polybutyrolactam Nanofiber with Excellent Biodegradability and Cell Growth for Sustainable Healthcare Textiles.

机构信息

State Key Laboratory of Separation Membranes and Membrane Processes, Key Laboratory of Advanced Braided Composites Ministry of Education, School of Textile Science and Engineering, Tiangong University, Tianjin 300387, China.

State Key Laboratory of Separation Membranes and Membrane Processes, School of Textile Science and Engineering, Tiangong University, Tianjin 300387, China.

出版信息

Biomacromolecules. 2024 Sep 9;25(9):5745-5757. doi: 10.1021/acs.biomac.4c00249. Epub 2024 Aug 22.

Abstract

The white pollution caused by unsustainable materials is a significant challenge around the globe. Here, a novel and fully biobased polybutyrolactam (PBY) nanofiber membrane was fabricated via the electrospinning method. As-spun PBY nanofiber membranes have good thermal stability, high porosity of up to 71.94%, and excellent wetting behavior. The biodegradability in soil, UV aging irradiation, and seawater was investigated. The PBY nanofiber membrane is almost completely degraded in the soil within 80 days, showing excellent degradability. More interestingly, γ-aminobutyric acid, as a healthcare agent with intrinsic hypotensive, tranquilizing, diuretic, and antidiabetic efficacy, can be detected in the degradation intermediates. In addition, the PBY nanofiber membrane also exhibits antibacterial ability against As a fully biomass-derived material, the PBY membrane has excellent biodegradable performance in various environments as well as negligible cytotoxicity and commendable cell proliferation. Our PBY nanofiber membrane shows great potential as biodegradable packaging and in vitro healthcare materials.

摘要

由不可持续材料造成的白色污染是全球面临的重大挑战。在这里,我们通过静电纺丝法制备了一种新型的、完全基于生物的聚丁内酯(PBY)纳米纤维膜。所制备的 PBY 纳米纤维膜具有良好的热稳定性,高达 71.94%的高孔隙率和优异的润湿性。研究了其在土壤中的生物降解性、紫外老化辐照和海水中的降解性。结果表明,PBY 纳米纤维膜在 80 天内几乎完全在土壤中降解,表现出优异的降解性。更有趣的是,在降解中间体中可以检测到γ-氨基丁酸,作为一种具有内在降压、镇静、利尿和抗糖尿病功效的保健剂。此外,PBY 纳米纤维膜对大肠杆菌和金黄色葡萄球菌还表现出抗菌能力。作为一种完全源自生物质的材料,PBY 膜在各种环境中具有优异的可生物降解性能,且细胞毒性可忽略不计,细胞增殖能力良好。我们的 PBY 纳米纤维膜在可生物降解包装和体外保健材料方面具有巨大的应用潜力。

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