State Key Laboratory of Separation Membranes and Membrane Processes, School of Materials Science and Engineering Tianjin Polytechnic University , Tianjin , China.
J Biomater Sci Polym Ed. 2019 Dec;30(17):1620-1635. doi: 10.1080/09205063.2019.1652793. Epub 2019 Aug 12.
Infection from bacterial resistance to antibiotics has given rise to a grave threat to human health in the world. It is vital to developing highly efficient antibacterial materials that are safe and biocompatible with humans and without bacterial resistance. In this study, nanofiber membranes of graphene oxide/polyacrylonitrile (GO/PAN) with highly efficient antibacterial activity were fabricated via electrospinning technique. As the spindle-knot structure of membranes formed by the addition of GO sheets increased, the hydrophilicity and surface roughness increased. The antibacterial test indicated that antibacterial ratios of 3GO/PAN membranes against and were 98.5% and 99.6%, respectively after contracting 24 h, with highly efficient antibacterial activity. Furthermore, the cell structures of adhered to the GO/PAN nanofiber surface changed significantly shrunk and deformed, and the number of cell were obviously less contrast than the pure PAN. The main antibacterial mechanism was GO of spindle-knot in nanofiber membranes produced ROS destroyed the physiological activities of the bacteria lead to death. The fabricated GO/PAN nanofiber membrane of this study is promising to develop to a kind of novel antibacterial materials.
细菌对抗生素的耐药性感染已经对全球人类健康造成了严重威胁。开发高效、安全、对人体具有生物相容性且不易产生细菌耐药性的抗菌材料至关重要。本研究通过静电纺丝技术制备了具有高效抗菌活性的氧化石墨烯/聚丙烯腈（GO/PAN）纳米纤维膜。随着 GO 片层的加入，纤维膜的纺锤结结构增加，亲水性和表面粗糙度增加。抗菌试验表明，经过 24 h 孵育，3GO/PAN 膜对 和 的抑菌率分别达到 98.5%和 99.6%，具有高效的抗菌活性。此外，黏附在 GO/PAN 纳米纤维表面的 细胞结构明显收缩变形，与纯 PAN 相比，细胞数量明显减少。主要的抗菌机制是纳米纤维膜中纺锤结状的 GO 产生 ROS，破坏细菌的生理活性，导致细菌死亡。本研究制备的 GO/PAN 纳米纤维膜有望开发成为一种新型抗菌材料。
