Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Science, SSIP Healthcare and Medicine Demonstration Zone, Zhongshan Tsuihang New District, Zhongshan 528400, PR China; Carbohydrate Drug Research Center, CAS Key Laboratory of Receptor Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, PR China; University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, PR China.
Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Science, SSIP Healthcare and Medicine Demonstration Zone, Zhongshan Tsuihang New District, Zhongshan 528400, PR China; Carbohydrate Drug Research Center, CAS Key Laboratory of Receptor Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, PR China; China School of Life Science and Technology, China Pharmaceutical University, Nanjing 211198, PR China.
Carbohydr Polym. 2024 Nov 1;343:122457. doi: 10.1016/j.carbpol.2024.122457. Epub 2024 Jul 5.
Pectic polysaccharides have long been a challenging subject of research in the field of macromolecular science, given their complex structures and wide range of biological effects. However, the extensive exploration of pectic polysaccharides has been limited due to the intricacy of their structures. In this comprehensive review, we aim to provide a thorough summary of the existing knowledge on pectic polysaccharides, with a particular focus on aspects such as classification, extraction methodologies, structural analysis, elucidation of biological activities, and exploration of target molecules and signaling pathways. By conducting a comprehensive analysis of existing literature and research achievements, we strive to establish a comprehensive and systematic framework that can serve as a reference and guide for further investigations into pectic polysaccharides. Furthermore, this review delves into the applications of pectic polysaccharides beyond their fundamental attributes and characteristics, exploring their potential in fields such as materials, food, and pharmaceuticals. We pay special attention to the promising opportunities for pectic polysaccharides in the pharmaceutical domain and provide an overview of related drug development research. The aim of this review is to facilitate a holistic understanding of pectic polysaccharides by incorporating multifaceted research, providing valuable insights for further in-depth investigations into this significant polymer.
果胶多糖因其复杂的结构和广泛的生物效应,长期以来一直是高分子科学领域极具挑战性的研究课题。然而,由于其结构的复杂性,对果胶多糖的广泛探索受到了限制。在这篇全面的综述中,我们旨在对果胶多糖的现有知识进行全面总结,特别关注分类、提取方法、结构分析、生物活性阐明以及靶分子和信号通路的探索等方面。通过对现有文献和研究成果进行综合分析,我们努力建立一个全面系统的框架,为进一步研究果胶多糖提供参考和指导。此外,本综述还探讨了果胶多糖除基本属性和特征之外的应用,探索了它们在材料、食品和制药等领域的潜在应用。我们特别关注果胶多糖在制药领域的有前途的机会,并概述了相关的药物开发研究。本综述的目的是通过综合多方面的研究,综合理解果胶多糖,为进一步深入研究这一重要聚合物提供有价值的见解。