韩国中年成年人睡眠时间、睡眠时间和睡眠潜伏期与代谢综合征的关联：一项横断面和纵向研究。

Association of sleep timing, sleep duration, and sleep latency with metabolic syndrome in middle-aged adults in Korea: A cross-sectional and longitudinal study.

作者信息

Baek Younghwa, Jeong Kyoungsik, Lee Siwoo

机构信息

KM Data Division, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea.

出版信息

Sleep Health. 2025 Feb;11(1):73-79. doi: 10.1016/j.sleh.2024.06.002. Epub 2024 Aug 22.

DOI:10.1016/j.sleh.2024.06.002

PMID:39174451

Abstract

OBJECTIVE

Sleep is a potential risk factor for metabolic syndrome. We investigated the associations of various sleep characteristics with the status and incidence of metabolic syndrome in middle-aged Koreans.

METHODS

Using data from a community-based Korean Medicine Daejeon Citizen Cohort study on participants aged 30-50years, cross-sectional (n = 1984) and longitudinal (n = 1216, median follow-up: 2.1years) analyses were performed. To study the association of metabolic syndrome and five components with various sleep characteristics, measured using the Pittsburgh Sleep Quality Index, we used Poisson and logistic regression and Cox proportional hazard regression analyses, adjusting for covariates.

RESULTS

Of 1984 participants, 66%, 19%, and 15% belonged to the non-metabolic syndrome, pre-metabolic syndrome, and metabolic syndrome groups, respectively. After covariate adjustments, the pre-metabolic syndrome group was associated with late mid-sleep time (≥5:00; prevalence ratios 1.61, 95% confidence interval 1.01-2.54) and late bedtime (≥2:00; prevalence ratios 1.55, 95% confidence interval 1.03-2.34), and the metabolic syndrome group was associated with long sleep latency (prevalence ratios 1.33, 95% confidence interval 1.03-1.73), poor sleep quality (prevalence ratios 1.38, 95% confidence interval 1.07-1.78), and early wake time (<6:00; prevalence ratios 1.29, 95% confidence interval 1.01-1.63). Longitudinal analysis of participants without metabolic syndrome at baseline indicated a significant increase in metabolic syndrome risk associated with very short sleep duration (<6 hours; hazard ratio 1.72, 95% confidence interval 1.06-2.79), long sleep latency (>30 minutes; hazard ratio 1.86, 95% confidence interval 1.1-3.12), and early wake time (<6:00 o'clock; hazard ratio 1.73, 95% confidence interval 1.01-2.97).

CONCLUSION

Sleep characteristics, such as short duration, long latency, and early wake time, were associated with an increased risk of metabolic syndrome in middle-aged adults.

摘要

目的

睡眠是代谢综合征的一个潜在风险因素。我们调查了韩国中年人群中各种睡眠特征与代谢综合征的状态及发病率之间的关联。

方法

利用一项基于社区的大田韩医市民队列研究中30至50岁参与者的数据，进行了横断面分析（n = 1984）和纵向分析（n = 1216，中位随访时间：2.1年）。为研究代谢综合征及其五个组分与使用匹兹堡睡眠质量指数测量的各种睡眠特征之间的关联，我们使用了泊松回归、逻辑回归和Cox比例风险回归分析，并对协变量进行了调整。

结果

在1984名参与者中，分别有66%、19%和15%属于非代谢综合征组、代谢综合征前期组和代谢综合征组。在对协变量进行调整后，代谢综合征前期组与睡眠中期较晚时间（≥5:00；患病率比1.61，95%置信区间1.01 - 2.54）和就寝时间较晚（≥2:00；患病率比1.55，95%置信区间1.03 - 2.34）相关，而代谢综合征组与入睡潜伏期长（患病率比1.33，95%置信区间1.03 - 1.73）、睡眠质量差（患病率比1.38，95%置信区间1.07 - 1.78）以及起床时间较早（<6:00；患病率比1.29，95%置信区间1.01 - 1.63）相关。对基线时无代谢综合征的参与者进行的纵向分析表明，睡眠持续时间极短（<6小时；风险比1.72，95%置信区间1.06 - 2.79）、入睡潜伏期长（>30分钟；风险比1.86，95%置信区间1.1 - 3.12）和起床时间较早（<6:00；风险比1.73，95%置信区间1.01 - 2.97）与代谢综合征风险显著增加相关。