Department of Preventive Medicine, Wonju College of Medicine, Yonsei University, Republic of South Korea.
Tohoku J Exp Med. 2011 Nov;225(3):187-93. doi: 10.1620/tjem.225.187.
Chronic sleep deprivation is increasingly common in industrialized societies. Short sleep duration has been associated with a number of negative health outcomes. The objectives of this study were to investigate the association between self-reported sleep duration and the presence of metabolic syndrome (combination of central obesity, triglyceride, high density lipoprotein, blood pressure, fasting plasma glucose) in adults during midlife. The Korean Genomic Rural Cohort (KGRC) is a cohort study of aged 40 to 70 years in rural Korea. This study focuses on the prevalence, incidence, and risk factors for chronic degenerative disorders, such as hypertension, diabetes, osteoporosis, respiratory diseases, and metabolic syndrome. The baseline sample of participants in the KGRC study was recruited in 2005-2006 (phase 1). Respondents were followed until 2008-2009 (phase 2). The final sample included 1,107 subjects: 386 males (34.9%) and 721 females (65.1%). The incidence rate of metabolic syndrome in our sample was 18.4% (21.2% for males and 16.9% for females). Subjects sleeping < 6 hours a day (HR: 1.798; 95% CI: 1.06-3.05) were significantly more likely to experience metabolic syndrome than participants sleeping 6 to 7.9 hours a day after controlling for potential covariates (age, body mass index, menopause, smoking, alcohol and physical activity). Shorter sleep duration was associated with the high incidence of metabolic syndrome among females only. In conclusion, shorter sleep duration may be a significant risk factor for the development of metabolic syndrome in women.
慢性睡眠剥夺在工业化社会中越来越普遍。睡眠时间短与许多负面健康后果有关。本研究的目的是调查中年成年人自我报告的睡眠时间与代谢综合征（中心性肥胖、甘油三酯、高密度脂蛋白、血压、空腹血糖的组合）之间的关联。韩国农村基因组队列（KGRC）是一项对韩国农村 40 至 70 岁人群的队列研究。本研究侧重于高血压、糖尿病、骨质疏松症、呼吸道疾病和代谢综合征等慢性退行性疾病的患病率、发病率和危险因素。KGRC 研究的基线样本于 2005-2006 年（第 1 阶段）招募。受访者一直随访到 2008-2009 年（第 2 阶段）。最终样本包括 1107 名受试者：386 名男性（34.9%）和 721 名女性（65.1%）。我们样本中代谢综合征的发病率为 18.4%（男性为 21.2%，女性为 16.9%）。与每天睡眠 6 至 7.9 小时的参与者相比，每天睡眠不足 6 小时的参与者（HR：1.798；95%CI：1.06-3.05）发生代谢综合征的风险明显更高，在控制了潜在的混杂因素（年龄、体重指数、绝经、吸烟、饮酒和体力活动）后。睡眠时间较短与女性代谢综合征的高发病率有关。总之，睡眠时间较短可能是女性代谢综合征发展的一个重要危险因素。
