Liu Liming, Zheng Yuguo
School of Biotechnology, Jiangnan University, Wuxi 214122, Jiangsu, China.
College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, Zhejiang, China.
Sheng Wu Gong Cheng Xue Bao. 2024 Aug 25;40(8):1-8. doi: 10.13345/j.cjb.240659.
Microbial chemical factories utilize engineering design principles to re-build natural production pathways, enabling the precise, quantitative, and efficient synthesis of chemicals. This is achieved through the optimization of synthetic pathways, the reconstruction of biochemical networks, the development of novel components, and the integration of pathways with cellular and environmental contexts. As a transformative approach to chemical production, microbial chemical factories play a critical role in establishing renewable raw material pathways for industrial economic development and advancing sustainable growth. This innovative model has become a strategic priority for technological advancement and industrial competitiveness in developed nations. This industry has expanded into diverse sectors, including pharmaceuticals, food production, chemicals, and energy. To showcase the most recent scientific advancements in the field of microbial chemical production and to promote the evolution of the bio-manufacturing industry, we organized a special issue entitled "Microbial Chemical Factories". This edition features the latest research conducted by domestic scientists, focusing on areas such as the synthesis of material monomers, pharmaceutical intermediates, functional food ingredients, organic acid biosynthesis, and the development and utilization of non-food feedstock. It provides reference and guidance for the further development of microbial chemical factories.
微生物化学工厂利用工程设计原理来重建天然生产途径，从而实现化学品的精确、定量和高效合成。这是通过优化合成途径、重建生化网络、开发新型组件以及将途径与细胞和环境背景相整合来实现的。作为一种变革性的化学生产方法，微生物化学工厂在为工业经济发展建立可再生原料途径和推动可持续增长方面发挥着关键作用。这种创新模式已成为发达国家技术进步和产业竞争力的战略重点。该行业已扩展到多个领域，包括制药、食品生产、化工和能源。为了展示微生物化学生产领域的最新科学进展并促进生物制造产业的发展，我们组织了一期名为“微生物化学工厂”的特刊。本期特刊展示了国内科学家的最新研究成果，重点关注材料单体合成、药物中间体、功能性食品成分、有机酸生物合成以及非食品原料的开发利用等领域。它为微生物化学工厂的进一步发展提供了参考和指导。
