Zhang Bo, Liao Yuzhe, Yu Haonan, Wang Guanghao, Liu Zhiqiang, Zheng Yuguo
The National and Local Joint Engineering Research Center for Biomanufacturing of Chiral Chemicals, Zhejiang University of Technology, Hangzhou 310014, Zhejiang, China.
Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, Zhejiang, China.
Sheng Wu Gong Cheng Xue Bao. 2024 Aug 25;40(8):2528-2551. doi: 10.13345/j.cjb.240166.
Vitamins are a class of organic substances essential for maintaining the normal physiological function of organisms. Most vitamins cannot be synthesized by the human body, and a small number of vitamins can only be synthesized in a limited manner, which cannot meet the body needs. Therefore, people need to take food or drugs containing vitamins to meet the body needs. Nowadays, vitamins are widely used in medicine, food or feed additives, cosmetics and other industries, and the demand for vitamins is growing. Vitamins are mainly produced by chemical synthesis and biosynthesis. Compared with chemical synthesis, biosynthesis of vitamins is praised for the environmental friendliness, high safety, and low costs. Therefore, it is of great practical significance to study the biosynthesis methods of vitamins. This paper reviews the research progress in the methods and summarizes the research results in the biosynthesis of water-soluble vitamins (B vitamins and vitamin C) in recent years and then makes an outlook on the future development in this field.
维生素是一类维持生物体正常生理功能所必需的有机物质。大多数维生素不能由人体合成，少数维生素只能以有限的方式合成，无法满足身体需求。因此，人们需要通过食用含维生素的食物或药物来满足身体需求。如今，维生素广泛应用于医药、食品或饲料添加剂、化妆品等行业，对维生素的需求不断增长。维生素主要通过化学合成和生物合成生产。与化学合成相比，维生素的生物合成因其环境友好、安全性高和成本低而受到赞誉。因此，研究维生素的生物合成方法具有重要的现实意义。本文综述了相关方法的研究进展，总结了近年来水溶性维生素（B族维生素和维生素C）生物合成的研究成果，并对该领域的未来发展进行了展望。
