Zhang Bo, Yu Haonan, Zhu Lidan, Zhu Yi, Liu Zhiqiang, Zheng Yuguo
The National and Local Joint Engineering Research Center for Biomanufacturing of Chiral Chemicals, Zhejiang University of Technology, Hangzhou 310014, Zhejiang, China.
Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, Zhejiang, China.
Sheng Wu Gong Cheng Xue Bao. 2024 Aug 25;40(8):2552-2569. doi: 10.13345/j.cjb.240155.
Vitamins are the essential organic substances to ensure the normal life activities of the human body. At present, vitamins are widely used in the pharmaceutical, food, animal farming, beauty and other industries, appearing in increasing application scenarios. Accordingly, the global demand for vitamins has also increased greatly. The current methods of vitamin production mainly include chemical synthesis and biosynthesis, with the latter being greener, more environmentally friendly, safer, and lower in energy consumption. Establishing the method for the biosynthesis of vitamins is of great scientific significance for achieving the goals of low carbon, energy saving, and emission reduction, as well as carbon emission peak and carbon neutrality in China. This paper reviews the research progress in the biosynthesis of vitamins, especially fat-soluble vitamins (vitamins A, D, E, and K), in recent years.
维生素是确保人体正常生命活动所必需的有机物质。目前,维生素广泛应用于制药、食品、畜牧养殖、美容等行业,应用场景日益增多。相应地,全球对维生素的需求也大幅增加。目前维生素的生产方法主要包括化学合成和生物合成,后者更绿色、更环保、更安全且能耗更低。建立维生素生物合成方法对于实现我国低碳、节能、减排以及碳排放达峰和碳中和目标具有重大科学意义。本文综述了近年来维生素生物合成,尤其是脂溶性维生素(维生素A、D、E和K)的研究进展。