Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Eur J Nutr. 2024 Dec;63(8):2871-2883. doi: 10.1007/s00394-024-03460-5. Epub 2024 Aug 23.
To investigate whether micronutrient intake from food as well as the regular uptake of specific vitamins and/or minerals are associated with leucocyte telomere length (LTL).
This is a cross-sectional study using data from 422,693 UK Biobank participants aged from 40 to 69 years old, during 2006-2010. LTL was measured as the ratio of telomere repeat number to a single-copy gene and was log-transformed and z-standardized (z-LTL). Information concerning supplement use was collected at baseline through the touchscreen assessment, while micronutrient intake from food were self-reported through multiple web-based 24 h recall diaries. The association between micronutrient intake or supplement use and z-LTL was assessed using multivariable linear regression models adjusting for demographic, lifestyle and clinical characteristics.
About 50% (n = 131,810) of the participants, with complete data on all covariates, self-reported regular supplement intake. Whilst overall supplement intake was not associated with z-LTL, trends toward shorter z-LTL with regular vitamin B (-0.019 (95% CI: -0.041; 0.002)) and vitamin B9 (-0.027 (-0.054; 0.000)) supplement intake were observed. z-LTL was associated with food intake of pantothenic acid (-0.020 (-0.033; -0.007)), vitamin B6 (-0.015 (-0.027; -0.003)), biotin (0.010 (0.002; 0.018)) and folate (0.016 (0.003; 0.030)). Associations of z-LTL with these micronutrients were differentiated according to supplement intake.
Negative associations equivalent to a year or less of age-related change in LTL between micronutrient intake and LTL were observed. Due to this small effect, the clinical importance of the associations and any relevance to the effects of vitamin and micronutrient intake toward chronic disease prevention remains uncertain.
探讨食物中微量营养素的摄入以及特定维生素和/或矿物质的定期摄入是否与白细胞端粒长度（LTL）有关。
这是一项横断面研究，使用了 2006 年至 2010 年期间来自英国生物库的 422693 名年龄在 40 至 69 岁的参与者的数据。LTL 作为端粒重复数与单拷贝基因的比值进行测量，并进行对数转换和 z 标准化（z-LTL）。通过触摸屏评估在基线时收集有关补充剂使用的信息，而通过多个基于网络的 24 小时回忆日记自我报告食物中的微量营养素摄入。使用多变量线性回归模型，在调整人口统计学、生活方式和临床特征后，评估微量营养素摄入或补充剂使用与 z-LTL 之间的关联。
约 50%（n=131810）的参与者，所有协变量的完整数据，自我报告定期补充剂摄入。虽然总体补充剂摄入与 z-LTL 无关，但观察到定期维生素 B（-0.019（95%CI：-0.041；0.002））和维生素 B9（-0.027（-0.054；0.000））补充剂摄入与 z-LTL 呈负相关趋势。z-LTL 与泛酸（-0.020（-0.033；-0.007））、维生素 B6（-0.015（-0.027；-0.003））、生物素（0.010（0.002；0.018））和叶酸（0.016（0.003；0.030））的食物摄入量有关。根据补充剂摄入情况，z-LTL 与这些微量营养素的相关性存在差异。
观察到微量营养素摄入与 LTL 之间的 LTL 与年龄相关变化相等的一年或更短的负相关。由于这种小的影响，这些关联的临床重要性以及它们与维生素和微量营养素摄入对慢性疾病预防的影响的任何相关性仍不确定。
