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Oral Oncol. 2023 Jul;142:106420. doi: 10.1016/j.oraloncology.2023.106420. Epub 2023 May 12.
3
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CA Cancer J Clin. 2023 Jan;73(1):17-48. doi: 10.3322/caac.21763.
4
Sex Differences in the Prevalence of Head and Neck Cancers: A 10-Year Follow-Up Study of 10 Million Healthy People.头颈癌患病率的性别差异：对1000万健康人群的10年随访研究。
Cancers (Basel). 2022 May 20;14(10):2521. doi: 10.3390/cancers14102521.
5
The impact of delayed diagnosis on the outcomes of oral cancer patients: a retrospective cohort study.延迟诊断对口咽癌患者结局的影响：一项回顾性队列研究。
Int J Oral Maxillofac Surg. 2021 May;50(5):585-590. doi: 10.1016/j.ijom.2020.08.010. Epub 2020 Sep 8.
6
Age at start of using tobacco on the risk of head and neck cancer: Pooled analysis in the International Head and Neck Cancer Epidemiology Consortium (INHANCE).起始吸烟年龄对头颈部癌症风险的影响：国际头颈部癌症流行病学联盟（INHANCE）的 pooled 分析。
Cancer Epidemiol. 2019 Dec;63:101615. doi: 10.1016/j.canep.2019.101615. Epub 2019 Oct 3.
7
Perineural Invasion and Perineural Tumor Spread in Head and Neck Cancer.头颈部癌症中的神经周围侵犯和肿瘤沿神经扩散。
Int J Radiat Oncol Biol Phys. 2019 Apr 1;103(5):1109-1124. doi: 10.1016/j.ijrobp.2018.12.009. Epub 2018 Dec 15.
8
Squamous cell carcinoma of the oral tongue in patients younger than 30 years: clinicopathologic features and outcome.30 岁以下患者的口腔舌部鳞状细胞癌：临床病理特征和结局。
Clin Otolaryngol. 2010 Aug;35(4):307-12. doi: 10.1111/j.1749-4486.2010.02164.x.
9
Changing trends in oral squamous cell carcinoma with particular reference to young patients: 1971-2006. The Emory University experience.口腔鳞状细胞癌的变化趋势，特别关注年轻患者：1971 - 2006年。埃默里大学的经验。
Head Neck Pathol. 2008 Jun;2(2):60-6. doi: 10.1007/s12105-008-0054-5. Epub 2008 May 1.
10
Trends in head and neck cancer incidence in Tianjin, China, between 1981 and 2002.1981年至2002年间中国天津市头颈癌发病率的变化趋势。
Head Neck. 2009 Feb;31(2):175-82. doi: 10.1002/hed.20946.

年轻头颈鳞状细胞癌患者的患者及肿瘤特征与预后的相关性

Association of Patient and Tumor Characteristics With Outcomes in Young Head and Neck Squamous Cell Carcinoma Patients.

作者信息

Hsieh Ronan W, Gooding William E, Nilsen Marci, Kubik Mark, Kelly Zahra, Sridharan Shaum, Skinner Heath, Iheagwara Uzoma, Zevallos Jose P, Duvvuri Umamaheswar, Kim Seungwon, Ferris Robert L, Zandberg Dan P

机构信息

Division of Hematology and Oncology, University of Washington School of Medicine, Seattle, WA, USA.

UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania, USA.

出版信息

Clin Otolaryngol. 2025 Jan;50(1):15-21. doi: 10.1111/coa.14215. Epub 2024 Aug 22.

DOI:10.1111/coa.14215
PMID:39175141
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11618290/
Abstract

INTRODUCTION

We retrospectively studied young patients with head and neck squamous cell carcinoma (HNSCC) to identify factors associated with disease-specific survival (DSS).

METHODS

Patient and tumor characteristics of patients aged ≤45 who received treatments for non-metastatic HNSCC were collected to identify factors associated with DSS. Proportional hazards regression was applied separately for surgical and non-surgical patients.

RESULTS

230 patients were included. Surgical and non-surgical patients had similar DSS. Higher pathologic stages, positive margins, perineural invasion (PNI), extranodal extension and negative HPV status were associated with worse DSS for surgical patients and negative HPV status for non-surgical patients. In the multivariate analysis, pathologic stages, positive margins, and PNI were associated with worse DSS in surgical patients.

CONCLUSION

Pathologic stages, positive margins, and PNI are independently associated with worse DSS in young surgical HNSCC patients. PNI is a uniquely strong prognostic factor for young patients.

摘要

引言

我们对年轻的头颈部鳞状细胞癌（HNSCC）患者进行了回顾性研究，以确定与疾病特异性生存（DSS）相关的因素。

方法

收集年龄≤45岁的非转移性HNSCC患者的患者和肿瘤特征，以确定与DSS相关的因素。分别对手术和非手术患者应用比例风险回归分析。

结果

共纳入230例患者。手术和非手术患者的DSS相似。对于手术患者，较高的病理分期、切缘阳性、神经周围侵犯（PNI）、结外扩展以及HPV阴性状态与较差的DSS相关；对于非手术患者，HPV阴性状态与较差的DSS相关。在多变量分析中，病理分期、切缘阳性和PNI与手术患者较差的DSS相关。

结论

病理分期、切缘阳性和PNI与年轻的手术HNSCC患者较差的DSS独立相关。PNI是年轻患者独特的强预后因素。