Department of Otolaryngology-Head and Neck Surgery, Rabin Medical Center, Petah Tiqwa, Israel.
Clin Otolaryngol. 2010 Aug;35(4):307-12. doi: 10.1111/j.1749-4486.2010.02164.x.
To assess the possible effect of young age on clinical behaviour and survival outcome of squamous cell carcinoma of the oral tongue.
Retrospective, case control study.
A major tertiary referral centre.
Eighty-five patients with oral tongue squamous cell carcinoma with at least 2 years of follow-up.
Clinical and histopathological staging, disease-free survival, disease-specific survival and overall survival.
Eleven patients (13%) were younger than 30 years. Compared to the older patients, they had a significantly worse N stage (P = 0.041), more perineural invasion (P = 0.012), and higher rates, though not significant, of treatment failure (46%, including 60% with distant metastases, versus 35%, nearly all locoregional) and mortality (100% of treatment failures versus 73%). There were no significant between-group differences in 5-year disease-free, disease-specific, and overall survival.
In this study, patients younger than 30 years of age presented with advanced tumour stages and with a different failure pattern compared to the older age group. This may be attributable to age-related biologic behaviour or delayed cancer diagnosis. Differences in disease free survival and overall survival could not be established.
评估年龄对口腔舌鳞癌临床行为和生存结局的可能影响。
回顾性病例对照研究。
主要的三级转诊中心。
85 例口腔舌鳞癌患者，随访至少 2 年。
临床和组织病理学分期、无病生存率、疾病特异性生存率和总生存率。
11 例（13%）患者年龄小于 30 岁。与老年患者相比，他们的 N 分期明显更差（P = 0.041），神经周围侵犯更多（P = 0.012），尽管无统计学意义，但治疗失败率（包括远处转移的 60%，而非局部区域的 35%）和死亡率（100%的治疗失败率与 73%）更高。两组患者 5 年无病生存率、疾病特异性生存率和总生存率无显著差异。
在这项研究中，年龄小于 30 岁的患者与老年患者相比，肿瘤分期更晚，且失败模式不同。这可能归因于与年龄相关的生物学行为或癌症诊断延迟。无法确定无病生存率和总生存率的差异。
