Shan Yidan, He Di, Yan Fengguo, Huang Weijia
Department of Oral & Maxillofacial Surgery, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Front Immunol. 2025 Jan 2;15:1522820. doi: 10.3389/fimmu.2024.1522820. eCollection 2024.
Early-onset head and neck squamous cell carcinoma (HNSCC) has been increasingly observed in recent years, exhibiting distinct tumor behavior and a unique tumor microenvironment (TME) compared to older age groups. Studies suggest that early-onset HNSCC is associated with specific risk factors and prognostic outcomes, while the underlying mechanisms driving these age-related differences remain unclear. In this review, we systematically examined original studies involving young HNSCC patient samples, focusing on the characteristics of the TME and potential for personalized immunotherapy. While further evidence is needed, our findings indicate that the TME in early-onset HNSCC often exhibits higher aggressiveness and immune suppression. Consequently, tailored immunotherapy may offer a promising therapeutic strategy for this distinct patient population.
近年来，早发性头颈部鳞状细胞癌（HNSCC）的发病率日益上升，与老年人群相比，其肿瘤行为和肿瘤微环境（TME）具有独特性。研究表明，早发性HNSCC与特定的风险因素和预后结果相关，然而，导致这些年龄相关差异的潜在机制仍不明确。在本综述中，我们系统地研究了涉及年轻HNSCC患者样本的原始研究，重点关注TME的特征和个性化免疫治疗的潜力。虽然还需要更多证据，但我们的研究结果表明，早发性HNSCC中的TME通常表现出更高的侵袭性和免疫抑制作用。因此，针对这一特殊患者群体的定制免疫治疗可能是一种有前景的治疗策略。
