Department of Vascular Surgery, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Clinical Research Center, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Int Wound J. 2024 Aug;21(8):e14913. doi: 10.1111/iwj.14913.
The disturbance of the inflammatory microenvironment is a frequent pathological trait of diabetic wounds, contributing to the emergence of numerous chronic illnesses. This is crucial in both the development and recovery of wounds caused by diabetes. This study aims to perform a bibliometric analysis of research on the inflammatory microenvironment within the domain of diabetic wounds (DW) over the past 10 years. The objective is to map out the current global research landscape, pinpoint the most significant areas of study and offer guidance for future research avenues. Our research involved querying the Web of Science Core Collection (WoSCC) database for all pertinent studies on the inflammatory microenvironment in diabetic wounds (DW). We utilized bibliometric tools such as CiteSpace, VOSviewer and R (version 4.3.1) to identify and highlight the most impactful studies in the field. The study encompassed a review of 1454 articles published from 2014 to 2023, highlighting China and the United States as pivotal nations in the research of the inflammatory microenvironment in diabetic wounds (DW). Within this sphere, the University of Michigan and Harvard University in the United States, along with Shanghai Jiaotong University in China, emerged as the most prolific institutions. WANG Y from China was identified as the most productive author, while KUNKEL SL from the United States received the most citations. The research primarily focuses on topics such as wound healing, repair processes, angiogenesis, oxidative stress and macrophage activity. Additionally, "macrophage" and "delivery" were pinpointed as the leading subjects with promising research potential in this area. Research on the inflammatory microenvironment of diabetic wounds is rapidly advancing through active international collaboration. The study of new mechanisms related to the inflammatory microenvironment and the development of novel materials for repair based on this microenvironment represent emerging fields of future research, particularly in terms of translational applications. This may offer guidance and novel perspectives for further research in the area of the diabetic wound inflammatory microenvironment.
糖尿病创面的炎症微环境紊乱是其常见的病理特征，也是导致多种慢性疾病发生的重要原因，这一特征在糖尿病创面的发生和恢复中都起着至关重要的作用。本研究旨在对过去 10 年糖尿病创面炎症微环境领域的研究进行文献计量分析，旨在绘制当前全球研究格局，确定研究的重点领域，并为未来的研究方向提供指导。我们通过检索 Web of Science 核心合集数据库（WoSCC），对糖尿病创面炎症微环境的所有相关研究进行了检索。我们利用 CiteSpace、VOSviewer 和 R（版本 4.3.1）等文献计量学工具，对该领域最具影响力的研究进行了识别和突出显示。该研究共纳入了 2014 年至 2023 年发表的 1454 篇文章，强调了中国和美国在糖尿病创面炎症微环境研究中的重要地位。在美国，密歇根大学和哈佛大学，以及中国的上海交通大学，是该领域最具影响力的机构。中国的王 Y 被确定为最具影响力的作者，而美国的 KUNKEL SL 获得了最多的引用。该研究主要集中在创面愈合、修复过程、血管生成、氧化应激和巨噬细胞活性等方面。此外，“巨噬细胞”和“输送”被确定为该领域具有潜在研究价值的主要课题。糖尿病创面炎症微环境的研究正在通过积极的国际合作迅速推进。研究与炎症微环境相关的新机制以及基于该微环境的新型修复材料的开发代表了未来研究的新兴领域，特别是在转化应用方面。这可能为糖尿病创面炎症微环境领域的进一步研究提供指导和新的视角。
