Department of Pulmonary and Critical Care Medicine, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China; Research Unit of Respiratory Disease, Central South University, Changsha, Hunan, China; Clinical Medical Research Center for Pulmonary and Critical Care Medicine in Hunan Province, Changsha, Hunan, China; Diagnosis and Treatment Center of Respiratory Disease, Central South University, Changsha, Hunan, China.
J Rehabil Med. 2024 Aug 22;56:jrm39953. doi: 10.2340/jrm.v56.39953.
To investigate whether an early comprehensive pulmonary rehabilitation intervention initiated during hospital admission is safe and effective for patients with acute exacerbation of chronic obstructive pulmonary disease.
Prospective randomized controlled study.
SUBJECTS/PATIENTS: Patients with acute exacerbation of chronic obstructive pulmonary disease.
In total, 108 patients were randomized to the early comprehensive pulmonary rehabilitation and usual care groups within 48 hours. The 6-min walking distance, quality of life, breathlessness, and inspiratory muscle strength were measured on admission and discharge. Any adverse events of pulmonary rehabilitation were recorded.
On discharge, the patients in the early comprehensive pulmonary rehabilitation group had a more significant improvement in the 6-min walking distance (47.5 vs 23.0, p = 0.04). There was no significant difference in quality of life and breathlessness between the 2 groups. In the early comprehensive pulmonary rehabilitation group, inspiratory muscle strength and peak inspiratory flow were significantly improved, and the changes were much more pronounced than in the usual care group. There were no adverse events.
Early comprehensive pulmonary rehabilitation is safe and effective for hospitalized patients with acute exacerbation of chronic obstructive pulmonary disease, and should be performed during the early stage of hospitalization.
探讨在住院期间早期开始综合肺康复干预对慢性阻塞性肺疾病急性加重患者是否安全有效。
前瞻性随机对照研究。
受试者/患者：慢性阻塞性肺疾病急性加重患者。
共 108 例患者在入院后 48 小时内随机分为早期综合肺康复组和常规护理组。入院和出院时测量 6 分钟步行距离、生活质量、呼吸困难和吸气肌力量。记录肺康复的任何不良事件。
出院时，早期综合肺康复组的 6 分钟步行距离明显改善（47.5 比 23.0，p=0.04）。两组的生活质量和呼吸困难无显著差异。在早期综合肺康复组，吸气肌力量和峰流速明显改善，变化明显大于常规护理组。没有不良事件发生。
早期综合肺康复对住院慢性阻塞性肺疾病急性加重患者安全有效，应在住院早期进行。
