Physical Therapy Department, School of Medicine, University of São Paulo, São Paulo, Brazil; University Hospital, University of São Paulo, São Paulo, Brazil.
Physical Therapy Department, School of Medicine, University of São Paulo, São Paulo, Brazil.
Arch Phys Med Rehabil. 2014 Sep;95(9):1638-45. doi: 10.1016/j.apmr.2014.05.007. Epub 2014 May 28.
To evaluate the effects of whole-body resistance training on exercise capacity, health-related quality of life (HRQOL), and muscle strength in patients hospitalized for exacerbation of chronic obstructive pulmonary disease.
Randomized controlled trial.
University hospital.
Patients (N=46) were randomized to either a control group (CG) or training group (TG), and 29 patients completed the study.
Training consisted of weight-lifting exercises for 6 muscle groups in the upper and lower limbs (2 sets of 8 repetitions each), and the initial load was set at 80% of the 1-repetition maximum load.
Patients were evaluated on the second day of hospitalization, at hospital discharge, and 30 days postdischarge. Patients were evaluated on the basis of the 6-minute walking distance (6MWD), HRQOL, muscle strength, systemic inflammatory markers, and level of physical activity in daily life (PADL).
The CG showed a reduction in the strength of lower-limb muscles (P<.05) but not in the 6MWD (P>.05). In contrast, patients from the TG improved strength in the lower-limb muscles and 6MWD during and 30 days after hospitalization (P<.05). The TG also improved the impact domain in HRQOL after hospitalization. No improvement in PADL was observed in the TG. Finally, a reduction in the blood levels of inflammatory markers was observed only in the TG after hospitalization.
Our results suggest that resistance training during hospitalization improves the 6MWD, HRQOL, and lower-limb muscle strength, without altering the levels of systemic inflammation. However, future research should explore this intervention in larger randomized trials.
评估全身抗阻训练对慢性阻塞性肺疾病加重住院患者运动能力、健康相关生活质量（HRQOL）和肌肉力量的影响。
随机对照试验。
大学医院。
将患者（N=46）随机分为对照组（CG）或训练组（TG），29 名患者完成了研究。
训练包括举重练习，针对上下肢的 6 个肌肉群（每组 2 组，每组 8 次重复），初始负荷设定为 1 次重复最大负荷的 80%。
患者在住院第二天、出院时和出院后 30 天进行评估。根据 6 分钟步行距离（6MWD）、HRQOL、肌肉力量、全身炎症标志物和日常生活中的体力活动水平（PADL）对患者进行评估。
CG 组下肢肌肉力量下降（P<.05），但 6MWD 无变化（P>.05）。相比之下，TG 组患者在住院期间和住院后 30 天内下肢肌肉力量和 6MWD 均得到改善（P<.05）。TG 组在住院后还改善了 HRQOL 的影响领域。TG 组的 PADL 无改善。最后，仅在住院后 TG 组观察到炎症标志物的血液水平降低。
我们的结果表明，住院期间的抗阻训练可改善 6MWD、HRQOL 和下肢肌肉力量，而不会改变全身炎症水平。然而，未来的研究应在更大的随机试验中探索这种干预措施。
