脂肪肝的长期常温机器灌注：迈向移植不可移植肝脏？ - Suppr

Long-term normothermic machine perfusion of fatty livers: towards transplanting untransplantable livers?

作者信息

Patrono Damiano, De Stefano Nicola, Vissio Elena, Gambella Alessandro, Romagnoli Renato

机构信息

General Surgery 2U - Liver Transplant Unit, Azienda Ospedaliero Universitaria Città della Salute e della Scienza di Torino, Turin, Italy.

Pathology Unit, Azienda Ospedaliero Universitaria Città della Salute e della Scienza di Torino, Turin, Italy.

出版信息

Hepatobiliary Surg Nutr. 2024 Aug 1;13(4):681-685. doi: 10.21037/hbsn-24-285. Epub 2024 Jul 22.

DOI:10.21037/hbsn-24-285

PMID:39175741

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11336520/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/decd/11336520/8b2e6fd620e2/hbsn-13-04-681-f1.jpg

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Long-term normothermic machine perfusion of fatty livers: towards transplanting untransplantable livers?脂肪肝的长期常温机器灌注：迈向移植不可移植肝脏？

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Activation of autophagy during normothermic machine perfusion of discarded livers is associated with improved hepatocellular function.在常温机器灌注废弃肝脏的过程中激活自噬与改善肝细胞功能有关。

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Evolution Under Normothermic Machine Perfusion of Type 2 Donation After Cardiac Death Livers Discarded as Nontransplantable.在常温机器灌注下，2 型心脏死亡供体捐献肝脏的演变，这些肝脏被视为不可移植而被丢弃。

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Manipulation of Lipid Metabolism During Normothermic Machine Perfusion: Effect of Defatting Therapies on Donor Liver Functional Recovery.常温机械灌注期间脂代谢的调控：去脂治疗对供体肝功能恢复的影响。

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Viability testing of discarded livers with normothermic machine perfusion: Alleviating the organ shortage outweighs the cost.采用常温机器灌注对废弃肝脏进行活力测试：缓解器官短缺比成本更为重要。

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Steatotic Donor Transplant Livers: Preservation Strategies to Mitigate against Ischaemia-Reperfusion Injury.脂肪变性供体肝移植：减轻缺血再灌注损伤的保护策略。

Int J Mol Sci. 2024 Apr 24;25(9):4648. doi: 10.3390/ijms25094648.

Improved assessment of donor liver steatosis using Banff consensus recommendations and deep learning algorithms.使用 Banff 共识建议和深度学习算法改善供体肝脂肪变性评估。

J Hepatol. 2024 Mar;80(3):495-504. doi: 10.1016/j.jhep.2023.11.013. Epub 2023 Nov 29.

Ann Surg. 2023 Nov 1;278(5):669-675. doi: 10.1097/SLA.0000000000006047. Epub 2023 Jul 27.

How to Preserve Steatotic Liver Grafts for Transplantation.如何保存用于移植的脂肪变性肝移植物

J Clin Med. 2023 Jun 12;12(12):3982. doi: 10.3390/jcm12123982.

A randomized-controlled trial of ischemia-free liver transplantation for end-stage liver disease.缺血性自由肝移植治疗终末期肝病的随机对照试验。

J Hepatol. 2023 Aug;79(2):394-402. doi: 10.1016/j.jhep.2023.04.010. Epub 2023 Apr 20.

Viability assessment and transplantation of fatty liver grafts using end-ischemic normothermic machine perfusion.使用缺血后常温机器灌注评估和移植肝脂肪化供肝。

Liver Transpl. 2023 May 1;29(5):508-520. doi: 10.1002/lt.26574. Epub 2022 Oct 10.

Outcome of liver transplantation with grafts from brain-dead donors treated with dual hypothermic oxygenated machine perfusion, with particular reference to elderly donors.脑死亡供者行低温氧合机器灌注保存后肝移植的效果，特别是老年供者。

Am J Transplant. 2022 May;22(5):1382-1395. doi: 10.1111/ajt.16996. Epub 2022 Feb 22.

Machine perfusion of the liver: applications in transplantation and beyond.肝脏的机器灌注：在移植及其他领域的应用

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An integrated perfusion machine preserves injured human livers for 1 week.一体化灌注机能将损伤的人类肝脏保存 1 周。

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Long-term normothermic machine perfusion of fatty livers: towards transplanting untransplantable livers?

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