Corica Domenico, Toscano Fabio, Moleti Mariacarla, Pepe Giorgia, Campenni Alfredo, Fadda Guido, Dionigi Gianlorenzo, Romeo Carmelo, Aversa Tommaso, Wasniewska Malgorzata
Pediatric Unit, Department of Human Pathology of Adulthood and Childhood "G. Barresi", University of Messina, Messina, Italy.
Endocrinology Unit, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
Front Pediatr. 2024 Aug 8;12:1388437. doi: 10.3389/fped.2024.1388437. eCollection 2024.
Thyroid nodules in children are less common than in adults but they are approximately two- to three-fold more likely to be malignant in children. Among thyroid nodular diseases, Plummer's adenoma occurs very rarely in pediatrics, and currently, there is no literature providing evidence of this diagnosis in patients with Prader-Willi syndrome (PWS). We report the case of a 9-year-old Caucasian boy affected by PWS presenting with a rapidly growing palpable mass in the thyroid lodge associated with subclinical hyperthyroidism. Laboratory and other examinations (thyroid ultrasound, fine-needle aspiration of the nodule, and scintigraphy) were strongly suggestive for Plummer's adenoma; therefore, the patient underwent left hemithyroidectomy surgery, and anatomo-pathological examination confirmed the diagnosis. Our case describes the first evidence of an isolated follicular adenoma in children with PWS. Surgery is the only therapeutic option in younger children. Further evidence is needed to assess the possible correlation between these two conditions and the existence of potential risk factors.
儿童甲状腺结节比成人少见，但儿童甲状腺结节恶变的可能性约为成人的两到三倍。在甲状腺结节性疾病中，普卢默腺瘤在儿科极为罕见，目前尚无文献能证实普拉德-威利综合征（PWS）患者有此诊断。我们报告了一例9岁患有PWS的白种男孩病例，其甲状腺部位出现一个可触及的快速生长肿块，并伴有亚临床甲状腺功能亢进。实验室检查及其他检查（甲状腺超声、结节细针穿刺及闪烁扫描）强烈提示为普卢默腺瘤；因此，该患者接受了左半甲状腺切除术，解剖病理学检查确诊。我们的病例描述了PWS患儿孤立性滤泡性腺瘤的首个证据。手术是年幼儿童唯一的治疗选择。需要更多证据来评估这两种情况之间可能的关联以及潜在危险因素的存在。
