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Search for singularity cells at the onset of brain disorders using whole-brain imaging.

作者信息

Hashimoto Hitoshi, Nakazawa Takanobu

机构信息

Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565-0871, Japan.

Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University, and University of Fukui, Suita, Osaka 565-0871, Japan.

出版信息

Biophys Physicobiol. 2024 Feb 2;21(Supplemental):e211003. doi: 10.2142/biophysico.bppb-v21.s003. eCollection 2024.

DOI:10.2142/biophysico.bppb-v21.s003
PMID:39175865
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11338687/
Abstract
摘要

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Volumetric trans-scale imaging of massive quantity of heterogeneous cell populations in centimeter-wide tissue and embryo.对厘米级组织和胚胎中大量异质细胞群体进行体积跨尺度成像。
Elife. 2025 Feb 3;13:RP93633. doi: 10.7554/eLife.93633.
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Parabrachial-to-parasubthalamic nucleus pathway mediates fear-induced suppression of feeding in male mice.臂旁核到苍白球内侧核通路介导雄性小鼠恐惧诱导的摄食抑制。
Nat Commun. 2022 Dec 30;13(1):7913. doi: 10.1038/s41467-022-35634-2.
3
Molecular basis of astrocyte diversity and morphology across the CNS in health and disease.中枢神经系统中星形胶质细胞多样性和形态的分子基础：在健康和疾病中的表现。
Science. 2022 Nov 4;378(6619):eadc9020. doi: 10.1126/science.adc9020.
4
Rare coding variation provides insight into the genetic architecture and phenotypic context of autism.罕见编码变异为自闭症的遗传结构和表型背景提供了深入了解。
Nat Genet. 2022 Sep;54(9):1320-1331. doi: 10.1038/s41588-022-01104-0. Epub 2022 Aug 18.
5
Molecular brain (micro report) oxytocin ameliorates impaired social behavior in a mouse model of 3q29 deletion syndrome.分子脑（微报告）：催产素可改善 3q29 缺失综合征小鼠模型的社交行为障碍。
Mol Brain. 2022 Mar 28;15(1):26. doi: 10.1186/s13041-022-00915-w.
6
Claustrum mediates bidirectional and reversible control of stress-induced anxiety responses.屏状核介导对应激诱导的焦虑反应的双向和可逆控制。
Sci Adv. 2022 Mar 18;8(11):eabi6375. doi: 10.1126/sciadv.abi6375.
7
Exploring rare cellular activity in more than one million cells by a transscale scope.通过跨尺度范围在超过一百万的细胞中探索罕见的细胞活动。
Sci Rep. 2021 Aug 16;11(1):16539. doi: 10.1038/s41598-021-95930-7.
8
Intranasal oxytocin administration ameliorates social behavioral deficits in a POGZ mouse model of autism spectrum disorder.鼻腔内给予催产素可改善自闭症谱系障碍 POGZ 小鼠模型的社交行为缺陷。
Mol Brain. 2021 Mar 16;14(1):56. doi: 10.1186/s13041-021-00769-8.
9
Pathogenic POGZ mutation causes impaired cortical development and reversible autism-like phenotypes.致病性 POGZ 突变导致皮质发育障碍和可逆转的自闭症样表型。
Nat Commun. 2020 Feb 26;11(1):859. doi: 10.1038/s41467-020-14697-z.
10
Psychiatric-disorder-related behavioral phenotypes and cortical hyperactivity in a mouse model of 3q29 deletion syndrome.3q29 缺失综合征小鼠模型中的精神障碍相关行为表型和皮质过度活跃。
Neuropsychopharmacology. 2019 Nov;44(12):2125-2135. doi: 10.1038/s41386-019-0441-5. Epub 2019 Jun 19.