Liu Lei, Xiang Yuqing, Xiong Lujing, Li Chao, Dai Wei, Hu Jinchuan, Shui Chunyan, Zhou Yuqiu, Wang Xu, Ma Linjie, Xu Nan, Hu Bintao, Cai Yongcong
Department of Head and Neck Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, China.
School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Front Psychol. 2024 Aug 8;15:1329175. doi: 10.3389/fpsyg.2024.1329175. eCollection 2024.
To evaluate the preoperative health-related quality of life (HRQoL) and influencing factors of HRQoL in patients undergoing thyroidectomy based on patient-reported outcomes.
Patients who were diagnosed and treated in Sichuan Cancer Hospital from February 2022 to December 2022 and were scheduled to undergo thyroidectomy were included. Each participant completed the basic information questionnaire and patient-reported outcome assessment scales before surgery. HRQoL was assessed using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-C30 (EORTC QLQ-C30), the Thyroid Cancer-Specific Quality of Life (THYCA-QoL), and the Hamilton Anxiety Scale (HAMA). The Wilcoxon rank sum test or the Kruskal-Wallis test was used to analyze the association between patient characteristics and HRQoL, and the variables with statistical significance were included in multiple linear regression analysis.
450 patients were included in the study. According to the analysis of the THYCA-QoL scores, the psychological subscale was the most complained about. Anxiety was the most common symptom of the HAMA. Factors associated with worse general QoL on the EORTC QLQ-C30 included nondiagnostic/unsatisfactory fine-needle aspiration (FNA) result. Planned lateral neck dissection and nondiagnostic/unsatisfactory FNA result were influential factors for preoperative anxiety. Males and longer sleep duration were associated with better thyroid cancer-specific QoL, better general QoL, and less anxiety.
The preoperative HRQoL of patients undergoing thyroidectomy was generally good. Females, insufficient sleep duration, planned lateral neck dissection, and nondiagnostic/unsatisfactory FNA result were associated with worse preoperative HRQoL.
基于患者报告结局评估甲状腺切除术患者术前健康相关生活质量（HRQoL）及其HRQoL的影响因素。
纳入2022年2月至2022年12月在四川省肿瘤医院诊断并计划接受甲状腺切除术的患者。每位参与者在手术前完成基本信息问卷和患者报告结局评估量表。使用欧洲癌症研究与治疗组织生活质量问卷-C30（EORTC QLQ-C30）、甲状腺癌特异性生活质量（THYCA-QoL）和汉密尔顿焦虑量表（HAMA）评估HRQoL。采用Wilcoxon秩和检验或Kruskal-Wallis检验分析患者特征与HRQoL之间的关联，并将具有统计学意义的变量纳入多元线性回归分析。
450例患者纳入研究。根据THYCA-QoL评分分析，心理子量表是抱怨最多的。焦虑是HAMA最常见的症状。EORTC QLQ-C30上与总体生活质量较差相关的因素包括细针穿刺（FNA）结果未明确诊断/不满意。计划行侧颈清扫术和FNA结果未明确诊断/不满意是术前焦虑的影响因素。男性和较长的睡眠时间与较好的甲状腺癌特异性生活质量、较好的总体生活质量和较少的焦虑相关。
甲状腺切除术患者术前HRQoL总体良好。女性、睡眠时间不足、计划行侧颈清扫术以及FNA结果未明确诊断/不满意与较差的术前HRQoL相关。
