Yang Xiongtao, Yang Qing, Tang Yuan, Ma Jing, Ye Huamei
Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610041, People's Republic of China.
Business School, Sichuan University, Chengdu, 610064, People's Republic of China.
Cancer Manag Res. 2021 Sep 7;13:6953-6967. doi: 10.2147/CMAR.S321988. eCollection 2021.
As most thyroid cancer patients survive for more than ten years, it has become increasingly important to understand whether the different surgery types have any effect on the quality of life (QoL) of patients.
Using observational data from head and neck surgery at the Sichuan Cancer Hospital in China, three scoring methods - sum scoring, domain-based scoring and IRT-based scoring, were employed to measure the QoL in differentiated thyroid cancer (DTC) patients and a propensity score matched analysis performed to explore the impact of surgery type on QoL as measured by the Treatment of Cancer Quality of Life core Questionnaire version 3.0 (EORTC QLQ-C30) and a disease-specific health-related quality of life questionnaire (THYCA-QoL).
No statistically significant patient QoL differences were found between the two surgery types regardless of which questionnaire was used and which scoring method was used (, using the EORTC QLQ-C30 and the sum scoring; , using the EORTC QLQ-C30 and the domain-based scoring; and , using the EORTC QLQ-C30 and the IRT-based scoring; , using the THYCA-QoL and the sum scoring; , using the THYCA-QoL and the domain-based scoring; and , using the THYCA-QoL and the IRT-based scoring).
This study confirmed that the surgery type (hemithyroidectomy or total thyroidectomy) for DTC patients did not appear to influence their general QoL.
由于大多数甲状腺癌患者存活超过十年，了解不同手术类型对患者生活质量（QoL）是否有影响变得越来越重要。
利用中国四川省肿瘤医院头颈外科的观察性数据，采用三种评分方法——总和评分、基于领域的评分和基于项目反应理论（IRT）的评分，来测量分化型甲状腺癌（DTC）患者的生活质量，并进行倾向得分匹配分析，以探讨手术类型对生活质量的影响，该影响通过癌症生活质量核心问卷第3.0版（EORTC QLQ-C30）和特定疾病的健康相关生活质量问卷（THYCA-QoL）来衡量。
无论使用哪种问卷和哪种评分方法，两种手术类型之间均未发现患者生活质量存在统计学上的显著差异（使用EORTC QLQ-C30和总和评分时，P = ；使用EORTC QLQ-C30和基于领域的评分时，P = ；使用EORTC QLQ-C30和基于IRT的评分时，P = ；使用THYCA-QoL和总和评分时，P = ；使用THYCA-QoL和基于领域的评分时，P = ；使用THYCA-QoL和基于IRT的评分时，P = ）。
本研究证实，DTC患者的手术类型（甲状腺半切术或全甲状腺切除术）似乎不会影响其总体生活质量。
