Universidade Federal do Maranhão São LuísMA Brazil Universidade Federal do Maranhão, São Luís, MA, Brazil.
Rev Bras Ginecol Obstet. 2024 Jul 26;46. doi: 10.61622/rbgo/2024rbgo57. eCollection 2024.
High-risk human papillomavirus (HPV) infection is associated with cervical cancer while low-risk HPV strains mostly cause benign lesions. Multiple studies have also associated HPV with coronary artery (CAD) disease in women. Furthermore, the climacteric period in women, triggers chronic inflammation and has major implications for CAD and associated lipid disorders. The association of HPV with coronary artery disease in climacteric women has few studies, and the objective of this review is to gather and analyse scientific data on the subject. This is an integrative review performed on PubMed and Google Scholar using the keywords "HPV", "coronary heart disease" and "climacteric", among these keywords the boolean operator AND and the publication date filter. (2018 onwards). Five articles were found, whose main results show presence of high-risk vaginal HPV in climacteric women. Climacterium and HPV were associated with a three-fold increased risk of CAD, as well as with factors related to menopause that promote atheroma formation, lipid disorders and chronic inflammation. Thus, these results support the association between HPV infection and CAD in climacteric women, possibly via chronic inflammation, hormonal factors related to menopause and dyslipidemia.
高危型人乳头瘤病毒（HPV）感染与宫颈癌相关，而低危型 HPV 株主要引起良性病变。多项研究还表明 HPV 与女性冠状动脉（CAD）疾病有关。此外，女性的更年期会引发慢性炎症，对 CAD 和相关脂质紊乱有重大影响。关于 HPV 与更年期女性冠心病的关联，研究较少，本综述的目的是收集和分析该主题的科学数据。这是一项在 PubMed 和 Google Scholar 上进行的综合综述，使用了“HPV”、“冠心病”和“更年期”等关键词，并使用了布尔运算符 AND 和出版物日期过滤器（2018 年及以后）。共发现 5 篇文章，其主要结果表明，更年期女性存在高危型阴道 HPV。更年期和 HPV 与 CAD 风险增加三倍有关，也与促进动脉粥样硬化形成、脂质紊乱和慢性炎症的与绝经相关的因素有关。因此，这些结果支持 HPV 感染与更年期女性 CAD 之间的关联，可能通过慢性炎症、与绝经相关的激素因素和血脂异常。
