Department of Physiology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, 03601 Martin, Slovak.
Biomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, 03601 Martin, Slovak.
Int J Mol Sci. 2019 Jul 30;20(15):3720. doi: 10.3390/ijms20153720.
Cervical cancer is associated with a causative role of human papillomavirus (HPV), which is a highly prevalent infection. Recently, women with a genital HPV infection were found to have increased incidence of cardiovascular diseases (CVD), including severe cardiovascular events such as myocardial infarction and stroke. The pathomechanisms of this relation are not yet fully understood, and may significantly affect the health of a large part of the population. Accelerated atherosclerosis is assumed to play a key role in the pathophysiology of this relationship. To identify high-risk groups of the population, it is necessary to stratify the CVD risk. Current algorithms, as widely used for the estimation of CVD risk, seem to be limited by the individual misclassification of high-risk subjects. However, personalised prediction of cardiovascular events is missing. Regarding HPV-related CVD, identification of novel sensitive biomarkers reflecting early atherosclerotic changes could be of major importance for such personalised cardiovascular risk prediction. Therefore, this review focuses on the pathomechanisms leading to HPV-related cardiovascular diseases with respect to atherosclerosis, and the description of potential novel biomarkers to detect the earliest atherosclerotic changes important for the prevention of CVD in HPV infection and cervical cancer.
宫颈癌与人乳头瘤病毒（HPV）的致病作用有关，HPV 是一种高度普遍存在的感染。最近，发现患有生殖器 HPV 感染的女性心血管疾病（CVD）的发病率增加，包括心肌梗死和中风等严重心血管事件。这种关系的发病机制尚不完全清楚，可能会对很大一部分人群的健康产生重大影响。加速的动脉粥样硬化被认为在这种关系的病理生理学中起关键作用。为了确定高危人群，有必要对 CVD 风险进行分层。目前的算法，如广泛用于 CVD 风险估计的算法，似乎受到高风险个体的个体分类错误的限制。然而，缺乏个性化的心血管事件预测。关于 HPV 相关的 CVD，识别反映早期动脉粥样硬化变化的新型敏感生物标志物对于这种个性化心血管风险预测可能非常重要。因此，本综述重点关注导致 HPV 相关心血管疾病的发病机制，以及描述潜在的新型生物标志物，以检测 HPV 感染和宫颈癌中预防 CVD 的重要早期动脉粥样硬化变化。
