Aogauchi R, Tsubota N, Yamashita C, Yoshikawa K, Ishii N, Nakamura K
Gan To Kagaku Ryoho. 1985 Jan;12(1):105-10.
Distribution of the FT-207 and 5-FU between plasma and lung tissue as well as tumor tissue was studied in 28 patients with lung cancer after administration of FT-207 preoperatively. Two methods of administration were employed, one is intravenous drip infusion (IV Group) (800 mg/day for three days) and the other is suppository (Supp Group) (750 mg 2/day for three days). The level of FT-207 was higher in plasma than in normal lung tissue or tumor tissue in IV Group. There was no difference in the level of FT-207 between plasma, normal lung tissue and tumor tissue in Supp Group. The level of 5-FU was higher in tumor tissue than in plasma both in IV Group and Supp Group. Furthermore, intravenous drip infusion was more effective method to give FT-207 because of higher level of 5-FU in tumor tissue than in normal tissue. Comparison of the tissue level in IV Group between two histologic types of tumor, i.e. squamous cell carcinoma and adenocarcinoma, disclosed that there was no significant difference in the concentration of FT-207 and 5-FU both in normal lung tissue and in tumor tissue.
对28例肺癌患者术前给予FT - 207后，研究了FT - 207和5 - 氟尿嘧啶（5 - FU）在血浆与肺组织以及肿瘤组织之间的分布情况。采用了两种给药方法，一种是静脉滴注（静脉滴注组）（800毫克/天，共三天），另一种是栓剂（栓剂组）（750毫克，每天2次，共三天）。静脉滴注组血浆中FT - 207的水平高于正常肺组织或肿瘤组织。栓剂组血浆、正常肺组织和肿瘤组织中FT - 207的水平没有差异。静脉滴注组和栓剂组肿瘤组织中5 - FU的水平均高于血浆。此外，由于肿瘤组织中5 - FU的水平高于正常组织，静脉滴注是给予FT - 207更有效的方法。对静脉滴注组两种组织学类型的肿瘤，即鳞状细胞癌和腺癌之间的组织水平进行比较，结果显示正常肺组织和肿瘤组织中FT - 207和5 - FU的浓度均无显著差异。
