Sonnex T S, Jones R L, Weddell A G, Dawber R P
Br Med J (Clin Res Ed). 1985 Jan 19;290(6463):188-90. doi: 10.1136/bmj.290.6463.188.
In a study of the time course and nature of the sensory loss after cryosurgery the forearms of nine normal subjects were treated with liquid nitrogen using freeze times currently employed in clinical practice in Britain. Ability to appreciate touch, pinprick, and cold in the treated areas was tested at regular intervals and biopsy samples taken to investigate the pathogenesis. Appreciation of all three modalities of sensation was initially reduced in all nine subjects for all freeze times, yet complete recovery occurred in the seven patients completing follow up. This recovery, however, took up to one and a half years for the longest freeze, with even a 10 second freeze taking up to 10 months. Patients may be reassured that sensory loss after cryosurgery for up to two periods of 30 seconds will almost certainly recover, though it may take up to 18 months to do so.
在一项关于冷冻手术后感觉丧失的时间进程和性质的研究中，对9名正常受试者的前臂使用了英国临床实践中目前采用的冷冻时间进行液氮治疗。定期测试治疗区域对触摸、针刺和冷觉的感知能力，并采集活检样本以研究发病机制。在所有9名受试者中，对于所有冷冻时间，最初这三种感觉模式的感知都有所降低，但在完成随访的7名患者中完全恢复。然而，对于最长的冷冻时间，这种恢复需要长达一年半的时间，即使是10秒的冷冻也需要长达10个月。患者可以放心，冷冻手术长达两个30秒的感觉丧失几乎肯定会恢复，尽管可能需要长达18个月的时间才能恢复。
