遗传风险对阿尔茨海默病 rs-fMRI 复杂性与 Tau 和淀粉样蛋白 PET 关系的影响。
Effect of Genetic Risk on the Relationship Between rs-fMRI Complexity and Tau and Amyloid PET in Alzheimer's Disease.
机构信息
USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
出版信息
J Alzheimers Dis. 2024;101(2):429-435. doi: 10.3233/JAD-240459.
Reduced functional magnetic resonance imaging (fMRI)-complexity in Alzheimer's disease (AD) progression has been demonstrated and found to be associated with tauopathy and cognition. However, association of fMRI-complexity with amyloid and influence of genetic risk (APOEɛ4) remain unknown. Here we investigate the association between fMRI-complexity, tau-PET, and amyloid-PET as well as influence of APOE genotype using multivariate generalized linear models. We show that fMRI-complexity has a strong association with tau but not amyloid deposition and that the presence of an APOEɛ4 allele enhances this effect. Thus fMRI-complexity provides a surrogate marker of impaired brain functionality in AD progression.
阿尔茨海默病（AD）进展中的功能磁共振成像（fMRI）复杂性降低已得到证实，并发现与tau 病和认知有关。然而，fMRI 复杂性与淀粉样蛋白的关联以及遗传风险（APOEɛ4）的影响仍不清楚。在这里，我们使用多变量广义线性模型研究了 fMRI 复杂性与 tau-PET 和淀粉样蛋白-PET 之间的关联以及 APOE 基因型的影响。我们表明，fMRI 复杂性与 tau 有很强的关联，但与淀粉样蛋白沉积无关，并且存在 APOEɛ4 等位基因增强了这种效应。因此，fMRI 复杂性为 AD 进展中大脑功能受损提供了替代标志物。
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